health

Remote Work – Not The Norm

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Nearly One in Five Americans Works From Home Regularly – https://www.statista.com/chart/35389/regular-remote-and-home-office-work/

I started writing my journal in 2005. One of the best things about keeping a journal is the ability to verify if memories from the past are accurate or the made up, mashups your brain creates as memories. Here’s my entry on Monday July 24 2006:

A 4:00 PM meeting with the Division head with an HR rep present is never a good thing. I immediately thought to myself:

“This is gonna suck.”

And it did, big time. I got whacked today.

And that’s how my WFH life began. When my work from home situation arises in conversation most are surprised to learn I’ve been WFH this long. I’m surprised how long I’ve been working from home!

I am convinced due to having a low stress working environment, better diet (NO office snacks/free food/lunches out), no commute, along with a host of other variables I just might be increasing my lifespan. I do know I get plenty of sleep on a regular routine basis.

Short sleep duration (< 7 h per night) was associated with a 14% increase in mortality risk compared to the reference of 7–8 h, with a pooled hazard ratio of 1.14 (95% CI 1.10 to 1.18). Conversely, long sleep duration (≥ 9 h per night) was associated with a 34% higher risk of mortality, with a hazard ratio of 1.34 (95% CI 1.26 to 1.42). Sex-specific analyses indicated that both short and long sleep durations significantly elevated mortality risk in men and women, although the effect was more pronounced for long sleep duration in women. Both short and long sleep durations are associated with increased all-cause mortality, though the degree of risk varies by sex. Imbalanced sleep increases mortality risk by 14–34%: a meta-analysis – Ungvari, Z., Fekete, M., Varga, P. et al. Imbalanced sleep increases mortality risk by 14–34%: a meta-analysis. GeroScience 47, 4545–4566 (2025). https://doi.org/10.1007/s11357-025-01592-y

Compounding Compounds the Problem

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Compound pharmacies that bulk produce weight-loss drugs without FDA approval are doing so without that oversight.  And because compounding pharmacies aren’t required to report instances of patient harm involving their medications, problems may go undetected.“It’s kind of like ‘Whack-A-Mole,’” said Al Carter, a pharmacist and executive director at the National Association of Boards of Pharmacy. He said state boards will only investigate when they receive a complaint.“There are bad actors out there, purporting to be compounding pharmacies that are licensed in specific states or have the credentials to be able to compound when in actuality they don’t,” said Carter. “My understanding is most licensed, legitimate pharmacies aren’t compounding” weight-loss medications. ‘Compounded’ weight-loss drugs are a growing problem for state regulators – https://stateline.org/2024/07/08/compounded-weight-loss-drugs-are-a-growing-problem-for-state-regulators/

A website sold patients obesity drugs at affordable rates. Now they’re paying the price.– https://www.npr.org/2025/02/08/nx-s1-5246124/a-website-sold-patients-obesity-drugs-at-affordable-rates-now-theyre-paying-the-price

“The two main goals of the medication are weight loss and diabetes management, so patients should stay on the lowest dosage possible until they feel like they’ve plateaued,” said Charu Sawhney, DO, MPH, an internal medicine physician with Harbor Health in Round Rock, Texas. When patients move up on the dosage too fast, they’re going to have more trouble, said Sawhney. “This is when we see the most severe side effects like the malnutrition and dehydration that can sometimes land patients in the hospital,” she said. Considerations for Prescribing GLP-1s Get More Complicated – Medscape – February 07, 2025 – https://www.medscape.com/viewarticle/considerations-prescribing-glp-1s-get-more-complicated

I admit as a Former Fat Man that the world of obesity and now a miracle drug to fight the disease fascinates the hell out of me. Caveat emptor!

It’s 8:00 AM…yes, I’m Thinking About Drinking

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Alcohol use is ubiquitous in the United States, with 84% of adults reporting use at some point. Alcohol use disorder (AUD) is a serious and persistent disease at the extreme end of alcohol use that contributes heavily to the burden on the healthcare system, with more than 200,000 hospitalizations each year due to the condition. About 6% of people in the United States have AUD. However, only 7.6% of patients with AUD seek treatment, although several pharmacologic and nonpharmacologic treatment options are available. Stephen Soreff. Rapid Rx Quiz: Alcohol Use Disorder Treatments – Medscape – Dec 30, 2024. https://reference.medscape.com/viewarticle/1002119

  • Overall mortality rates increased from 10.7 (95% CI, 10.6-10.8) per 100,000 in 1999 to 21.6 (95% CI, 21.4-21.8) per 100,000 in 2020, representing a significant twofold increase.
  • Adults aged 55-64 years demonstrated both the steepest increase and highest absolute rates in both 1999 and 2020.
  • American Indian and Alaska Native individuals experienced the steepest increase and highest absolute rates among all racial groups.
  • The West region maintained the highest absolute rates in both 1999 and 2020, despite the Midwest showing the largest increase. Edited by Lora McGlade. US Alcohol-Related Deaths Double Over Two Decades, With Notable Age and Gender Disparities – Medscape – November 21, 2024. https://www.medscape.com/viewarticle/us-alcohol-related-deaths-double-over-two-decades-notable-2024a1000l98?

Nearly 500 years ago, Swiss physician and chemist Paracelsus expressed the basic principle of toxicology: “All things are poison and nothing is without poison; only the dose makes a thing not a poison.” This is often condensed to: “The dose makes the poison.” It means that a substance that contains toxic properties can cause harm only if it occurs in a high enough concentration. https://www.chemicalsafetyfacts.org/health-and-safety/the-dose-makes-the-poison/

Dry January? If you’re doing this trendy behavior you know you drank too much this past holiday season.

Cancer warnings on alcohol? No one will read them.

Trust your intuition. If you’ve ever felt like you drink too much alcohol then you do.

1-800-662-HELP or text 988 for SAMHSA’s National Helpline.

Prostate Cancer Diagnosis? Eat Less Omega-6 fats and More Omega-3 fats

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To determine whether diet or supplements can play a role in managing prostate cancer, the UCLA-led team conducted a prospective clinical trial, called CAPFISH-3, that included 100 men with low risk or favorable intermediate risk prostate cancer who chose active surveillance. Participants were randomly assigned to either continue their normal diet or follow a low omega-6, high omega-3 diet, supplemented with fish oil, for one year.

The findings, published in the Journal of Clinical Oncology, show that a diet low in omega-6 and high in omega-3 fatty acids, combined with fish oil supplements, significantly reduced the growth rate of prostate cancer cells in men with early-stage disease.

University of California – Los Angeles Health Sciences. “A low omega-6, omega-3 rich diet and fish oil may slow prostate cancer growth.” ScienceDaily. http://www.sciencedaily.com/releases/2024/12/241213211326.htm (accessed December 13, 2024)

Another reminder I should get my PSA level checked.

My Fat Cells Have a Memory

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Even after drastic weight loss, the body’s fat cells carry the ‘memory’ of obesity, research1 shows — a finding that might help to explain why it can be hard to stay trim after a weight-loss programme.

This memory arises because the experience of obesity leads to changes in the epigenome — a set of chemical tags that can be added to or removed from cells’ DNA and proteins that help to dial gene activity up or down. For fat cells, the shift in gene activity seems to render them incapable of their normal function. This impairment, as well as the changes in gene activity, can linger long after weight has dropped to healthy levels, a study published today in Nature reports.

Fat cells have a ‘memory’ of obesity — hinting at why it’s hard to keep weight off – www.nature.com/articles/d41586-024-03614-9

For the geeks, here’s a link to the original study – https://doi.org/10.1038/s41586-024-08165-7

Even without this study I already knew my fat cells have a memory because they are constantly trying to make me gain weight.

GLP-1 – Compounded or Brand-Name?

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Caroline Apovian, MD, co-director of the Center for Weight Management and Wellness at Brigham and Women’s Hospital and professor of medicine at Harvard Medical School, Boston.

“Doctors who are obesity medicine specialists like myself in academic centers do not prescribe compounded semaglutide or tirzepatide,” she said.

Many of the compounded prescriptions, she said, come from telehealth virtual–only companies interested in profits.

GLP-1 Prescribing Decisions: Compounded or Brand-Name? – Medscape – November 14, 2024 – https://www.medscape.com/viewarticle/glp-1-prescribing-decisions-compounded-or-brand-name-2024a1000krd?

To be clear, all of my GLP-1 posts are not anti-pharma. If you can afford these medications and they work for you on your weight loss journey that’s great. Just be aware of the possible side effects and the fact these medications are for life. You will regain all that you’ve lost if you stop taking the drug.

Here’s the link to Complications? What Complications? (just another GLP-1 receptor agonist post)

Mind The Gaps

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The Food and Drug Administration is warning consumers not to use any drugs made by a compounding pharmacy in California after regulators realized the pharmacy was making drugs that need to be sterile—particularly injectable drugs—without using sterile ingredients or any sterilization steps.

The products made by the pharmacy, Fullerton Wellness LLC, in Ontario, California, include semaglutide, which is intended to mimic brand-name weight-loss and diabetes drugs Wegovy and Ozempic. Fullerton also made tirzepatide, which is intended to mimic weight-loss and diabetes drugs Zepbound and Mounjaro. Drugmaker shut down after black schmutz found in injectable weight-loss drug — https://arstechnica.com/health/2024/11/drugmaker-shut-down-after-black-schmutz-found-in-injectable-weight-loss-drug/

I’ve read the FDA advisory. The FDA warns patients and health care professionals not to use compounded drugs from Fullerton Wellness — https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-patients-and-health-care-professionals-not-use-compounded-drugs-fullerton-wellness

  1. If you’re injecting what you believe is a weight loss medication do you pay any attention to who the manufacturer is?
  2. Do you read any of the FDA drug alerts and statements?
  3. The FDA names the compounding facility but does not name of any clinics or online purveyors who may be selling you tainted and non-sterile drugs.
  4. If you ask your online provider questions will you get honest answers?
  5. Is losing a few pounds worth the risk?
  6. Have you considered the possibility that the side effects you’re having are not just normal side effects from a GLP-1 type compounded drug and may be from an impure product?

Yikes.

Cannabis and Impaired Brain Development

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The adolescent brain is particularly vulnerable to cannabis, especially today’s higher-potency products, which put teens at risk for impaired brain development; mental health issues, including psychosis; and cannabis use disorder (CUD).  That was the message delivered by Yasmin Hurd, PhD, director of the Addiction Institute at Mount Sinai in New York, during a May 6 press briefing at the American Psychiatric Association (APA) 2024 annual meeting. 

“We’re actually in historic times in that we now have highly concentrated, highly potent cannabis products that are administered in various routes,” Hurd told reporters. Tetrahydrocannabinol (THC) concentrations in cannabis products have increased over the years, from around 2%-4% to 15%-24% now, Hurd noted. High-Potency Cannabis Tied to Impaired Brain Development, Psychosis, CUD – Medscape – May 13, 2024. https://www.medscape.com/viewarticle/high-potency-cannabis-tied-impaired-brain-development-2024a1000935

Earlier posts on this topic:

Marijuana is Too Strong (THC turbocharged)

Cannabis Use and Psychosis Risk

Cannabis Use and Psychosis Risk (Aussie Version)

Reefer Madness

Food for Thought (and memories)

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Favorite Meals May Trigger Memories in People with Dementia

Mealtime can provide opportunities to connect with someone experiencing memory loss and tap into deeply rooted memories. “If you’re going to make your father’s favorite meal, think about how you can delve into it as an experience,” Aguirre says. Dr. Kramer notes that several senses associated with cooking and eating dishes, including smell and taste, are closely related to memory. Both the olfactory bulb, the main receiving center for smell, and the insular cortex and frontal operculum (also called the gustatory cortex), responsible for perception of taste, are closely connected to the amygdala, an area involved in emotional learning. The olfactory nerve, which conveys the sense of smell to the brain, is also close to the hippocampus, one of the most important brain structures for memory. And the combined effect of smell and taste—what neuroscientists who study this field call “flavor”—can be especially powerful at conjuring long-held memories charged with emotion, says Joel Salinas, MD, MBA, FAAN, assistant professor of neurology at NYU Langone Health and chief medical officer at Isaac Health, a clinic in New York City for brain health and memory problems.Favorite Meals May Trigger Memories in People with Dementia – https://www.brainandlife.org/articles/food-may-trigger-memories-in-people-with-dementia

Yogurt and CSBMs (Complete Spontaneous Bowel Movements)

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In a randomized controlled trial, the probiotic Bifidobacterium animalis subsp. lactis—used in many probiotic products, including Dannon’s Activia yogurts—did nothing to improve bowel health in people with constipation, according to data from a randomized triple-blind placebo-controlled clinical trial published Wednesday in JAMA Network Open. Popular gut probiotic completely craps out in randomized controlled trial – https://arstechnica.com/health/2024/10/popular-gut-probiotic-completely-craps-out-in-randomized-controlled-trial/

Here’s a lesson in the need to read the original study. I found this statement from the researchers:

The 2 study groups were very similar with respect to baseline characteristics. The participants had a low dietary fiber intake (9 g/d), which is in line with observations by others (11.7 g/d) and well below recommended levels (25.0 g/d).14 This may be a contributing factor to the bowel movement problems experienced by the participants. Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824333

IMO the low dietary fiber intake in this shitting study leads me to think the entire study results were…crappy.

BTW yesterday I had two CSBMs. That’s what I get for eating a bowl of black eye peas http://garyskitchen.net/2022/01/16/vegetarian-badass-black-eyed-peas-2022/ and a baked sweet potato in the same day.