Atrial Fibrillation – Circulation Research

Source: Atrial Fibrillation | Circulation Research

Abstract

The past 3 decades have been characterized by an exponential growth in knowledge and advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis requires a vulnerable atrial substrate and that the formation and composition of this substrate may vary depending on comorbid conditions, genetics, sex, and other factors. Population-based studies have identified numerous factors that modify the atrial substrate and increase AF susceptibility. To date, genetic studies have reported 17 independent signals for AF at 14 genomic regions. Studies have established that advanced age, male sex, and European ancestry are prominent AF risk factors. Other modifiable risk factors include sedentary lifestyle, smoking, obesity, diabetes mellitus, obstructive sleep apnea, and elevated blood pressure predispose to AF, and each factor has been shown to induce structural and electric remodeling of the atria. Both heart failure and myocardial infarction increase risk of AF and vice versa creating a feed-forward loop that increases mortality. Other cardiovascular outcomes attributed to AF, including stroke and thromboembolism, are well established, and epidemiology studies have championed therapeutics that mitigate these adverse outcomes. However, the role of anticoagulation for preventing dementia attributed to AF is less established. Our review is a comprehensive examination of the epidemiological data associating unmodifiable and modifiable risk factors for AF and of the pathophysiological evidence supporting the mechanistic link between each risk factor and AF genesis. Our review also critically examines the epidemiological data on clinical outcomes attributed to AF and summarizes current evidence linking each outcome with AF.

Childhood obesity quadruples risk of developing type 2 diabetes- ScienceDaily

Children with obesity face four times the risk of developing type 2 diabetes compared to children with a body mass index (BMI) in the normal range, according to a study published in the Journal of the Endocrine Society.

Source: Childhood obesity quadruples risk of developing type 2 diabetes: Large-scale UK study examines link between body mass index, metabolic health — ScienceDaily

I’m screwed again.

Expanding waistlines and metabolic syndrome: Researchers warn of new ‘silent killer’: Caused by overweight and obesity, metabolic syndrome affects 40 percent of Americans age 40 and older — ScienceDaily

For optimal health, the waist should measure less than 40 inches for men and 35 inches for women.

Source: Expanding waistlines and metabolic syndrome: Researchers warn of new ‘silent killer’: Caused by overweight and obesity, metabolic syndrome affects 40 percent of Americans age 40 and older — ScienceDaily