SIDD, SIRD, MOD, AND MARD – DM2 Subgroups

Type 2 diabetes (T2D) was recently reclassified into severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD), which have different risk of complications. We explored whether DNA methylation differs between these subgroups and whether subgroup-unique methylation risk scores (MRSs) predict diabetic complications.

Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns That Associate With Future Diabetic Complications — https://doi.org/10.2337/dc21-2489

More acronyms!

Just Another Hump Day…Sweet

Scientists have demonstrated that normal brain aging is accelerated by approximately 26% in people with progressive type 2 diabetes compared with individuals without the disease.

eLife. “Type 2 diabetes accelerates brain aging and cognitive decline.” ScienceDaily. http://www.sciencedaily.com/releases/2022/05/220525080527.htm (accessed May 25, 2022)

Makes you wonder if improving your diet will help.

Many adults can achieve remission of type 2 diabetes with a primary intervention consisting of a diet that emphasizes whole, plant-based foods, according to a new publication from the American College of Lifestyle Medicine (ACLM).

Experts Endorse Plant-Based Diet for Type 2 Diabetes Remission — https://www.medscape.com/viewarticle/974591?src=rss#vp_1

But we all know how hard lifestyle changes can be. Maybe best to just listen to some music.

Combination of biomarkers can identify common cognitive disease — Health Secrets of a SuperAger

In recent years, subcortical small-vessel disease has become an increasingly common cognitive diagnosis. Researchers at University of Gothenburg have now shown that it is possible to identify patients with the disease by combining two biomarkers that are measured in spinal fluid and blood, increasing the potential for both treatment and development of medication. Photo by […]

Combination of biomarkers can identify common cognitive disease — Health Secrets of a SuperAger

I found a blogger who is older than me.

Hell yeah I’m gonna follow him.

Stay as Thin as You Can as Long as You Can

Based on the evidence from clinical trials weight loss (typically 15 kg or greater) is the main driver and predictor of remission.

Dietary strategies for remission of type 2 diabetes: A narrative review — https://doi.org/10.1111/jhn.12938

A weight loss program can lead to type 2 diabetes remission, even in individuals with a normal body mass index (BMI), via loss of body fat, particularly in the liver and pancreas, shows a UK study.

Type 2 Diabetes Remission Possible For Those With Lower BMI — https://www.medscape.com/viewarticle/971599?src=rss#vp_1

The title of this post is a direct quote from an Endocrinologist who at the time was practicing in Dallas Texas. I asked if he had any advice for me to reduce my risk of developing diabetes.

“Stay as thin as you can as long as you can.”

These words have stuck with me ever since.

Was SARS-COV-2 the Reason Why People Forgot How to Drive?

The U.S. Department of Transportation’s National Highway Traffic Safety Administration released its 2020 annual traffic crash data, showing that 38,824 lives were lost in traffic crashes nationwide. That number marks the highest number of fatalities since 2007. 

https://www.transportation.gov/briefing-room/nhtsa-releases-2020-traffic-crash-data

In Pandemic Year One we had the highest number of traffic fatalities since 2007.

Correlation is not causation. The post title is a click bait joke.

Merkel Cell Carcinoma (MCC)

Patients treated for Merkel cell carcinoma (MCC) face a five-year recurrence rate of 40% — markedly higher than the recurrence rates for melanoma and other skin cancers, according to research published today in JAMA Dermatology.

University of Washington School of Medicine/UW Medicine. “Patients with rare skin cancer face 40% recurrence rate.” ScienceDaily. http://www.sciencedaily.com/releases/2022/02/220223111226.htm (accessed February 24, 2022).

Covid Protocols

COVIDprotocols.org was launched by a team from Brigham and Women’s Hospital (BWH) in March, 2020 to create open access adaptable protocols for the management of COVID19 patients, based on BWH guidelines and multidisciplinary committee discussions. In spring of 2020, Partners In Health (PIH) also published the guides for COVID-19, focused on COVID-19 care in resource-limited settings. In December, 2020, COVIDprotocols.org partnered with UCSF’s Institute for Global Health Sciences and Partners in Health (PIH) to combine the best content from UCSF’s USAID-STAR sponsored OpenCriticalCare.org and the PIH COVID19 Guides to create COVIDprotocols.org v2.0. This updated resource for COVID-19 includes content relevant to all practice settings and presents information in ways to facilitate easier utilization in learning and practice. The BWH-specific protocols still exist and are available at BWH.covidprotocols.org.

https://covidprotocols.org/en/about/

I like the dashboard https://opencriticalcare.org/covid-dashboard/

Disclaimer: I am not a medical doctor and this blog and the information contained herein are intended and designed for educational purposes only. DO NOT rely on this information to replace professional medical advice, diagnosis, and/or treatment protocols.

Long Term Cannabis Use and Lung Damage

The findings come from the long-running Dunedin Multidisciplinary Health and Development Study, which has documented cannabis use and measured lung function throughout adult life up to age 45 in more than 1000 individuals born in Dunedin in 1972/73.

University of Otago. “How long-term cannabis use can damage lungs.” ScienceDaily. http://www.sciencedaily.com/releases/2022/02/220203192317.htm (accessed February 4, 2022).

Inhaling hot smoke into your lungs over a long period of time. What could possibly go wrong?

The App That Helps Me Be a More Patient Centered Physician — A Country Doctor Writes:

One of the most rewarding things I do in my clinic happens on my iPhone. When I sit down with a middle aged patient to talk about their cardiovascular risk, I open the risk calculator created by the American Heart Association and the American College of Cardiology. I talk my way through as I enter […]

The App That Helps Me Be a More Patient Centered Physician — A Country Doctor Writes:

The risk calculator is quite useful but I re-blogged this post for its link to the Hale study, which was news to me. This study published in 2004 showed older people between the ages of 70 and 90 who followed a Mediterranean diet have 50% lower rate of all-cause and cause-specific mortality than people who dine on the SAD Western diet. The four primary risk factors were diet, moderate alcohol intake, physical activity, and non-smoking.

Lifestyle matters.