PCSK9 Inhibitors

There’s also the issue of cost. The medicines are expected to come with a price tag of $7,000 to $12,000 per patient per year, according to the Wall Street Journal’s Pharmalot blog, costing the US health system as much as $23 billion a year. “These injectable drugs are already viewed by payers as potential budget busters along the lines of treatments for hepatitis C and some cancers,” Ed Silverman wrote.

via There’s still a lot we don’t know about the new cholesterol-lowering drugs – Vox.

Untreated Sleep Apnea Boosts Risk of Heart Disease, Stroke | Medpage Today

Untreated Sleep Apnea Boosts Risk of Heart Disease, Stroke | Medpage Today.

Compared with OSA-negative patients, untreated OSA was associated with an 86% higher mortality risk (adjusted hazard ratio 1.86, 95% CI 1.81 to 1.91), and treated OSA was associated with a 35% higher mortality risk (aHR 1.35, 95% CI 1.21 to 1.51), wrote Miklos Z. Molnar, MD, PhD, of the University of Tennessee Health Science Center in Memphis, and colleagues, in the journal Thorax.

Untreated OSA also was associated with a 3.5 times higher risk of incident coronary heart disease (aHR 3.54, 95% CI 3.40 to 3.69), and a 3.5 times higher risk of incident strokes (aHR 3.48, 95% CI 3.28 to 3.64), while treated OSA was associated with a threefold higher risk of incident CHD (aHR 3.06, 95% CI 2.62 to 3.56) and 3.5-fold higher risk of incident strokes (aHR 3.50, 95% CI 2.92 to 4.19). The risk of incident kidney disease also was significantly higher in untreated (aHR 2.27, 95% CI 2.19 to 2.36) and treated OSA (aHR 2.79, 95% CI 2.48 to 3.13).

The #1 Problem Among College Students Is Now Anxiety – Business Pundit

“They can’t tolerate discomfort or having to struggle,” Dan Jones, director of counseling and psychological services at Appalachian State University in Boone, North Carolina, told the New York Times. “A primary symptom is worrying, and they don’t have the ability to soothe themselves.” In 2010, a national study showed that nearly half of college students seeking counseling had serious mental illness. Those students outnumbered a 2000 study by 100%.

via The #1 Problem Among College Students Is Now Anxiety – Business Pundit.

Anxious Students Strain College Mental Health Centers – NYTimes.com.

More Venlafaxine please.

Long-term Mortality Risk After Hyperglycemic Crisis Episodes in Geriatric Patients With Diabetes: A National Population-Based Cohort Study

Long-term Mortality Risk After Hyperglycemic Crisis Episodes in Geriatric Patients With Diabetes: A National Population-Based Cohort Study.

CONCLUSIONS – Patients with diabetes had a higher mortality risk after HCE during the first 6 years of follow-up. Referral for proper education, better access to medical care, effective communication with a health care provider, and control of comorbidities should be done immediately after HCE.