Study finds electronic cigarettes damage brain stem cells (in cultured mouse neural stem cells)

A research team has found that electronic cigarettes, often targeted to youth and pregnant women, produce a stress response in neural stem cells, which are critical cells in the brain.

Study finds electronic cigarettes damage brain stem cells – UC Riverside research on mouse neural stem cells has implications for nicotine use

Hmmm………

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Longer daily fasting times improve health and longevity (in mice)

The scientists randomly divided 292 male mice into two diet groups. One group received a naturally sourced diet that was lower in purified sugars and fat, and higher in protein and fiber than the other diet. The mice in each diet group were then divided into three sub-groups based on how often they had access to food. The first group of mice had access to food around the clock. A second group of mice was fed 30 percent less calories per day than the first group. The third group was meal fed, getting a single meal that added up to the exact number of calories as the round-the-clock group. Both the meal-fed and calorie-restricted mice learned to eat quickly when food was available, resulting in longer daily fasting periods for both groups.

The scientists tracked the mice’s metabolic health through their lifespans until their natural deaths and examined them post-mortem. Meal-fed and calorie-restricted mice showed improvements in overall health, as evidenced by delays in common age-related damage to the liver and other organs, and extended longevity. The calorie-restricted mice also showed significant improvement in fasting glucose and insulin levels compared to the other groups. Interestingly, the researchers found that diet composition had no significant impact on lifespan in the meal fed and calorie restricted groups.

Source article here.

One of my neighbors is a mouse researcher.  I bet he’s really excited this weekend.

The NIH webpage on caloric restriction and fasting diets is here.

Binge-eating mice reveal obesity clues

For example, when offered chocolate for just one hour per day, the animals will compulsively ‘binge’, consuming as much chocolate in one hour as they would over a whole day if it was continually available. They also showed inflexible behaviours, similar to those seen in addiction, choosing to wait for chocolate while ignoring freely available standard chow. Yet, at the same time, the chocolate did not seem to satiate hunger as well as regular food.

The team found that animals on the high fat or chocolate diet also changed their daily routines. They were more likely to eat during the daytime — mice are usually nocturnal and feed at night — and they ate shorter more frequent ‘snacks’ rather than larger, longer-spaced meals.

We had friends over for dinner on Saturday.  While at the store shopping for provisions I saw some gelato on sale for 99 cents.

$0.99!  The only flavor on sale was chocolate.  I bought some.

The next night I had to have some chocolate gelato.  Because it was there!

The mice have proven what I already know.

Read the source article here.

Diet Soda May Alter Our Gut Microbes And Raise The Risk Of Diabetes : The Salt : NPR

Now, a new study published in the journal Nature introduces a new idea: Diet sodas may alter our gut microbes in a way that increases the risk of metabolic diseases such as Type 2 diabetes — at least in some of us.

In the paper, researchers at the Weizmann Institute of Science in Israel describe what happened when they fed zero-calorie sweeteners, including saccharin, aspartame and sucralose, to mice.

“To our surprise, [the mice] developed glucose intolerance,” Weizmann researcher Eran Elinav tells us.

Artificial sweeteners induce glucose intolerance by altering the gut microbiota : Nature : Nature Publishing Group.

Diet Soda May Alter Our Gut Microbes And Raise The Risk Of Diabetes : The Salt : NPR.