Neurodegenerative Copathology

About 20 years ago, neuropathologists began to report an inconvenient finding in the autopsied brains of people with dementia: Most have evidence of more than one disease. Studies since have shown the brains of up to half of people diagnosed with Alzheimer’s disease also have a key feature of Parkinson’s disease—deposits of the protein alpha synuclein. At the same time, up to half of Parkinson’s patients who develop dementia have elevated levels of beta amyloid and tau proteins, hallmarks of Alzheimer’s. Most dementia patients have multiple brain diseaseshttps://www.science.org/content/article/most-dementia-patients-have-multiple-brain-diseases-how-should-they-be-treated

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Death by Parkinson Disease

Parkinsons mm6835a6-F

From 1999 to 2017, age-adjusted death rates for Parkinson disease among adults aged ≥65 years increased from 41.7 to 65.3 per 100,000 population. Among men, the age-adjusted death rate increased from 65.2 per 100,000 in 1999 to 97.9 in 2017. Among women, the rate increased from 28.4 per 100,000 in 1999 to 43.0 in 2017. Throughout 1999–2017, the death rates for Parkinson disease for men were higher than those for women.

Source: National Center for Health Statistics, National Vital Statistics System, Mortality Data 1999–2017. https://www.cdc.gov/nchs/data_access/vitalstatsonline.htm.

QuickStats: Age-Adjusted Death Rates for Parkinson Disease Among Adults Aged ≥65 Years — National Vital Statistics System, United States, 1999–2017. MMWR Morb Mortal Wkly Rep 2019;68:773. DOI: http://dx.doi.org/10.15585/mmwr.mm6835a6external icon.