Increased Mortality of Patients with Childhood-onset Inflammatory Bowel Diseases, Compared With the General Population

The researchers identified patients with inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn’s disease between the years 1964 and 2014 via the Swedish patient register. Using these data, they compared mortality rates in about 9,400 children who developed IBD with those of other children.

Their results show that children who developed IBD before the age of 18 have a three to five-fold higher mortality rate than people without IBD, both during childhood and into adulthood. This translates to a 2.2-year reduction in life expectancy in individuals monitored up to the age of 65.

Source article.

Study abstract.Study abstract.

NEJM Resident e-Bulletin Teaching Topics 11.03.11

The next time you get asked by a sales professional why you rated her client for ulcerative colitis pull out this cheat sheet for talking points.

Q. What is the risk of cancer in patients with ulcerative colitis?

A. On the basis of data from referral centers, the cumulative risk of colorectal cancer among patients with chronic ulcerative colitis may reach 20 to 30% at 30 years, but the incidence rate is much lower in population-based series (approximately 2%). Risk factors for cancer include a long duration of disease, regardless of clinical activity; extensive involvement; a young age at onset; severe inflammation; the presence of primary sclerosing cholangitis; and a family history of colorectal cancer.