PodMed: A Medical News Roundup From Johns Hopkins.
This week’s topics include treating reduced blood supply to the heart, fit versus fat myth debunked, chickenpox vaccine impact, and treating anemia in people with heart disease.
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Lexiscan (regadenoson) and Adenoscan (adenosine): Drug Safety Communication – Rare but Serious Risk of Heart Attack and Death
BACKGROUND: Lexiscan and Adenoscan are FDA approved for use during cardiac nuclear stress tests in patients who cannot exercise adequately. Lexiscan and Adenoscan help identify coronary artery disease. They do this by dilating the arteries of the heart and increasing blood flow to help identify blocks or obstructions in the heart’s arteries. Lexiscan and Adenoscan cause blood to flow preferentially to the healthier, unblocked or unobstructed arteries, which can reduce blood flow in the obstructed artery. In some cases, this reduced blood flow can lead to a heart attack, which can be fatal. RECOMMENDATIONS: Screen all nuclear stress test candidates for their suitability to receive Lexiscan or Adenoscan. Avoid using these drugs in patients with signs or symptoms of unstable angina or cardiovascular instability, as these patients may be at greater risk for serious cardiovascular adverse reactions. Cardiac resuscitation equipment and trained staff should be available before administering Lexiscan or Adenoscan.
Long-Term Complications and Mortality in Young-Onset Diabetes
CONCLUSIONS – Young-onset T2DM is the more lethal phenotype of diabetes and is associated with a greater mortality, more diabetes complications, and unfavorable cardiovascular disease risk factors when compared with T1DM.
via Long-Term Complications and Mortality in Young-Onset Diabetes.
HbA1c and the Risks for All-Cause and Cardiovascular Mortality in the General Japanese Population
High HbA1c levels were associated with increased risk for all-cause mortality and death from CVD, coronary heart disease, and cerebral infarction in general East Asian populations, as in Western populations.
via HbA1c and the Risks for All-Cause and Cardiovascular Mortality in the General Japanese Population.
Subarachnoid Hemorrhage in Type 1 Diabetes
The incidence of nonaneurysmal SAH is high among patients with type 1 diabetes. Our findings suggest that nonaneurysmal SAH is a distinct new microvascular complication in type 1 diabetes.
Obstructive Sleep Apnea and Diabetic Nephropathy
OSA is independently associated with DN in type 2 diabetes. eGFR declined faster in patients with OSA. Nitrosative stress may provide a pathogenetic link between OSA and DN. Interventional studies assessing the impact of OSA treatment on DN are needed.
Swedish Obese Subjects Study Findings on 15-Year Diabetes Remission and Relapse Rates After Bariatric Surgery | Physician’s Weekly
Bipolar Disorder Linked to Early Death
All-cause mortality was 2.3-fold elevated among women and 2.0-fold higher among men with the psychiatric condition compared with the rest of Sweden after adjusting for other factors, they wrote.
Mediterranean Diet May Protect Kidneys
In a prospective cohort study, patients whose eating habits were closer to the tenets of a Mediterranean diet had about a 50% reduced odds of developing chronic kidney disease (CKD) over 7 years compared with those whose diets didn\’t resemble the fruit-and-vegetable-rich, low-saturated-fat diet, according to Minesh Khatri, MD, of Columbia University Medical Center, and colleagues.
Obesity Week!
The New DIETs (New Dietary Interventions to Enhance the Treatments for Weight Loss) Study is the first randomized trial that will compare how these four diets — none of which restrict calories — can influence body weight.
Obesity experts are anticipating answers on whether a vegan or vegetarian diet will offer better weight loss than a pescatarian or omnivorous one, experts told MedPage Today in the run-up to Obesity Week here.
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