Diabetic foot ulcers occur as a result of various factors, such as mechanical changes in conformation of the bony architecture of the foot, peripheral neuropathy, and atherosclerotic peripheral arterial disease, all of which occur with higher frequency and intensity in the diabetic population. Diabetic foot lesions are responsible for more hospitalizations than any other complication of diabetes. Among patients with diabetes, 15% develop a foot ulcer, and 12%-24% of individuals with a foot ulcer require amputation. Diabetes is the leading cause of nontraumatic lower-extremity amputations in the United States.
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FDA Clears CAD Screening Test – Medpage Today
FDA Clears CAD Screening Test | Medpage Today.
Lipoprotein-associated phospholipase A2 (Lp-PLA2)
Causes and Evaluation of Mildly Elevated Liver Transaminase Levels – American Family Physician
Causes and Evaluation of Mildly Elevated Liver Transaminase Levels – American Family Physician.
Nice article on the subject of mildly elevated liver enzymes.
Guiding Principles for Diabetes Care – NDEP
Guiding Principles for Diabetes Care | NDEP.
The guiding principles are available online or in pdf format.
OncoBriefs: Hookah Risk
OncoBriefs: Hookah Risk, Brain Cancer, Lung Cancer.
Urinary concentration of the benzene metabolite S-phenylmercapturic acid (SPMA) was more than four times greater in hookah smokers and two times greater in people exposed to secondhand hookah smoke, when compared with people who had no exposure. The findings put a damper on enthusiasm for hookah as a safer alternative to cigarettes, as reported online in Cancer Epidemiology, Biomarkers and Prevention.
Many Statin Eligible Patients Aren’t Getting Them
WOSCOPS at 20 Years Shows ‘Lifetime’ Benefit of Statins
JAMA – Nonobstructive Coronary Artery Disease and Risk of Myocardial Infarction
JAMA Network | JAMA | Nonobstructive Coronary Artery Disease and Risk of Myocardial Infarction.
Conclusions and Relevance In this cohort of patients undergoing elective coronary angiography, nonobstructive CAD, compared with no apparent CAD, was associated with a significantly greater 1-year risk of MI and all-cause mortality. These findings suggest clinical importance of nonobstructive CAD and warrant further investigation of interventions to improve outcomes among these patients.
Snorting bupropion – The Poison Review
Snorting bupropion | The Poison Review.
The abuse of bupropion by pulverizing and snorting the medication has been described at least as far back as 2002. Bupropion inhibits re-uptake of dopamine and norepinephrine, but apparently has little or no effect on serotonin. It is abused for its psychotropic effects that resemble those of amphetamine and cocaine..
A hallmark of overdose with sustained-release or extended-release bupropion formulations is delayed onset of seizures — sometimes more than 8 hours after ingestion. When these preparations are crushed and insufflated, absorption is rapid and manifestations would be expected to come on more quickly.
– See more at: http://www.thepoisonreview.com/2014/11/12/snorting-bupropion/#sthash.35NLtujG.dpuf
Effect of Body Mass Index on Insulin Secretion or Sensitivity and Diabetes – American Journal of Preventive Medicine
Background
Although the association between obesity and diabetes is well known, the factors predisposing to diabetes in non-obese Asians are less clearly characterized.
Conclusions
Individuals with normal BMI may develop diabetes mainly through IIS, whereas individuals with high BMI may develop diabetes primarily through IR.
I am so screwed.
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