underwriting

Emergency Medicine News – THC Dosing of Edible Marijuana in Colorado is Insane.

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Avoid couchlock! Four things to know about cannabis pharmacology | The Poison Review.

Recently, the New York Times’ Pulitzer Prize-winning columnist Maureen Dowd got into trouble in Denver when she overdosed on a cannabis candy bar and experienced 8 hours of paranoia and couchlock.

Toxicology Rounds: Four Things Maureen Dowd Should Have Know… : Emergency Medicine News.

THC dosing of edible marijuana in Colorado is insane. Richard Zane, MD, the chairman of emergency medicine at the University of Colorado Medical Center in Denver, said on the National Public Radio talk show On Point that the amount of THC in some marijuana edibles is completely irrational. The usual recommended moderate starting dose is approximately 10 mg THC, and some cookies can contain six doses and some lollipops as many as 10. Dr. Zane said the university’s ED sees out-of-state marijuana tourists every day who present with bad reactions to THC, such as agitation, unremitting violent vomiting, hallucinations, and psychosis.

And finally, a link to Maureen Dowd’s column.

Don’t Harsh Our Mellow, Dude – NYTimes.com.

In March, a 19-year-old Wyoming college student jumped off a Denver hotel balcony after eating a pot cookie with 65 milligrams of THC. In April, a Denver man ate pot-infused Karma Kandy and began talking like it was the end of the world, scaring his wife and three kids. Then he retrieved a handgun from a safe and killed his wife while she was on the phone with an emergency dispatcher.

JAMA – Treating Prescription Opioid Dependence

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JAMA Network | JAMA | Treating Prescription Opioid Dependence.

Conclusions and Relevance This study represents a rigorous experimental evaluation of outpatient buprenorphine stabilization, brief taper, and naltrexone maintenance for treatment of PO dependence. Results suggest that a meaningful subset of PO-dependent outpatients may respond positively to a 4-week

 

Naltrexone maintenance?  I bet they’ll lost weight too.

http://underwritingsolutionsllc.com/2014/09/14/fda-approves-bupropionnaltrexone-contrave-for-obesity/

Deaths From Narcotic Painkillers Quadrupled in Past Decade: CDC – WebMD

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Deaths From Narcotic Painkillers Quadrupled in Past Decade: CDC – WebMD.

Deaths from overdoses of drugs such as hydrocodone (Vicodin), morphine and oxycodone (Oxycontin) climbed from 1.4 per 100,000 people to 5.4 per 100,000, according to the U.S. Centers for Disease Control and Prevention.

That means about 3,000 people died in 1999 from unintentional overdoses. By 2011, that number was up to nearly 12,000 deaths, the report said.

FDA Okays Naloxegol Movantik in Opioid-Induced Constipation

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If you read the source article you’ll never look at constipation the same way ever again. Better dig deeper to find out why your applicant is constipated.  It may not be just a horrible diet and lack of dietary fiber.

And yet another FDA approved drug to counteract adverse effects from another FDA approved drug.

FDA Okays Naloxegol Movantik in Opioid-Induced Constipation.

The US Food and Drug Administration (FDA) has approved naloxegol (Movantik, AstraZeneca Pharmaceuticals), a peripherally acting opioid receptor antagonist, for the treatment of opioid-induced constipation (OIC) in adults with chronic noncancer pain.

OIC is a common adverse effect of opioid use. An estimated 40% to 80% of patients receiving long-term opioid therapy experience OIC, which can be severe enough to cause discontinuation of opioid therapy.

British pair found murdered on Thai resort

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British pair found murdered on Thai resort.

“It was the first time this has happened on the island. I have never seen anything like this,” the staff member added, requesting anonymity.


No, it is not the first time.  See second article.

British tourists ‘murdered’ in Thailand: The sinister streak lurking beneath seeming paradise – News & Advice – Travel – The Independent.

Their deaths take to 13 the number of British visitors to Thailand murdered in the past five years in what the Foreign Office calls “vicious, unprovoked attacks by gangs”.