FDA Adds Diabetes Warning to Statin Labels

The diabetes warning has been rumored as a possibility since the findings from the JUPITER trial of rosuvastatin revealed an unexpected 27% increase in new onset diabetes among patients randomized to the statin.That finding was especially perplexing because JUPITER was a study of statins in patients who had no history of cardiovascular disease, the so-called healthy patient trial. Moreover, based on the JUPITER results, the FDA approved rosuvastatin for primary prevention.The FDA said hyperglycemia was also observed among patients treated with 40-mg atorvastatin in a substudy of PROVE-IT TIMI 22, and a meta-analysis of data from 13 statin trials “reported that statin therapy was associated with a 9% increased risk for incident diabetes.”

via Medical News:FDA Adds Diabetes Warning to Statin Label – in Cardiovascular, Dyslipidemia from MedPage Today.

Sagicor Life Acquiring PEMCO’s Life Insurance Business

Sagicor Life Insurance Co. has an agreement to buy the policies and clients of PEMCO Life Insurance Co. from its parent company in Washington State as the latter firm exists the life insurance market.

Tampa-based Sagicor is buying about 10,000 term and whole life policies, along with about 7,500 clients, from PEMCO Mutual Insurance Co., a Washington State-based company.

via Sagicor Life acquiring PEMCO’s life insurance policies, clients | Insurance & Financial Advisor I IFAwebnews.com.

Effect of Aspirin on Vascular and Nonvascular Outcomes Meta-analysis

Conclusion: Despite important reductions in nonfatal MI, aspirin prophylaxis in people without prior CVD does not lead to reductions in either cardiovascular death or cancer mortality. Because the benefits are further offset by clinically important bleeding events, routine use of aspirin for primary prevention is not warranted and treatment decisions need to be considered on a case-by-case basis.

via Arch Intern Med — Abstract: Effect of Aspirin on Vascular and Nonvascular Outcomes: Meta-analysis of Randomized Controlled Trials, February 13, 2012, Seshasai et al. 172 3: 209.

Latin America: Where the world’s jobs are

Latin America: Where the world’s jobs are – CSMonitor.com.

So far, 200 entrepreneurs from 30 different countries have traveled to Chile to try to get their ideas off the ground through Start-Up Chile. The program aims to fund 1,000 entrepreneurs by 2014, and not only benefits the grantees – 80 percent of whom are foreigners – but is a boon to Chile, too, says spokeswoman Brenna Loury.

Interesting little article that offers minimal facts to back up the author’s assertion in the title.  How does 200 entrepreneurs equal “where the world’s jobs are”?

No Age Limit on Benefits of Eating Well

Older people who eat properly are likely to live longer.

That’s the implication of a study looking at mortality and eating habits among a cohort of nearly 4,000 people 65 and older, according to Luis Afonso, MD, of Wayne State University in Detroit, and colleagues.

After an average follow-up of 13 years, participants with a good diet had lower rates of all-cause and cardiovascular mortality, compared with those who had a poor diet, Afonso and colleagues reported in the Feb. 13 issue of Archives of Internal Medicine.

via Medical News:No Age Limit on Benefits of Eating Well – in Primary Care, Diet & Nutrition from MedPage Today.

I’ll take fries with that.

Biomarkers May Help Heart Failure Risk Prediction

After accounting for the clinical risk score, several echocardiographic findings were independently associated with incident heart failure HRs 1.11 to 2.91, P≤0.001 for all:

  • Reduced left ventricular ejection fraction
  • Abnormal mitral inflow E/A peak velocity ratio a measure of diastolic function
  • Enlarged left atrium Increased left ventricular mass

These variables were used to create an echocardiographic score.Elevated levels of NT-proBNP also were independently associated with heart failure risk HR 1.61 as a continuous variable and HR 2.7 for values greater than 190 pg/mL, P

via Medical News:Biomarkers May Help Heart Failure Risk Prediction – in Cardiovascular, CHF from MedPage Today.