Month: December 2020
The Pandemic Will Not End Soon – a Case Study in Finger Pointing and Blame Games
Some vaccine experts, though, said they are not surprised by the speed of vaccine distribution so far. “It had to go this way,” Paul Offit, a professor of pediatrics at Children’s Hospital of Philadelphia, told STAT. “We had to trip and fall and stumble and figure this out.”
Claire Hannan, executive director of the Association of Immunization Managers, said some of the gap between doses administered and delivered is likely due to a program run by CVS and Walgreens to vaccinate those in nursing homes. States participating in the program have to set aside 50% of their doses, which Hannan said could account for a share of the difference between doses shipped and doses administered nationally.
“I don’t think it’s bad,” she said of the pace of distribution so far. “I think it was always going to be like this. And I think that this is actually the easy part.”
Frustration over vaccine rollout builds, as new variant reported in U.S. for first time — https://www.statnews.com/2020/12/29/public-health-experts-grow-frustrated-with-pace-of-covid-19-vaccine-rollout/?utm_campaign=rss
We are definitely so screwed.
The Pandemic Will Not End Soon — Over half of U.S. adults ‘unlikely’ to get COVID vaccine under emergency use authorization
The coronavirus vaccine is finally a real thing and millions of people have already received it. While the rollout has the world cheering, researchers from Virginia Commonwealth University finds many Americans aren’t exactly chomping at the bit to be the first in line for the vaccine under an emergency use authorization. Their survey reveals 53.1 percent are definitely, likely, or somewhat unwilling to get the shot under emergency use conditions.
Over half of U.S. adults ‘unlikely’ to get COVID vaccine under emergency use authorization — https://www.studyfinds.org/half-adults-unlikely-to-get-covid-vaccine/
Journal Reference
Willingness to get the COVID-19 vaccine with and without emergency use authorization
Published:November 19, 2020 DOI:https://doi.org/10.1016/j.ajic.2020.11.018
We are so screwed.
New variant does not increase reinfection risk, disease severity, deaths — Science Chronicle
Preliminary results from a cohort study show no statistically significant difference in hospitalisation, 28-day case fatality and reinfection between the new variant and wild-type comparator cases. Preliminary results from a cohort study show no statistically significant difference in hospitalisation and 28-day case fatality between cases with the new variant (VOC 201212/01) and wild-type comparator cases. […]
New variant does not increase reinfection risk, disease severity, deaths — Science Chronicle
Phase 3 trial of Novavax investigational COVID-19 vaccine opens
In animal tests, NVX-CoV2373 vaccination produced antibodies that blocked the coronavirus spike protein from binding to the cell surface receptors targeted by the virus, preventing viral infection. In results(link is external) of a Phase 1 clinical trial published in the New England Journal of Medicine, NVX-CoV2373 was generally well-tolerated and elicited higher levels of antibodies than those seen in blood samples drawn from people who had recovered from clinically significant COVID-19. NVX-CoV2373 also is being evaluated in a Phase 2b trial in South Africa, now fully enrolled with 4,422 volunteers, and data from a Phase 1/2 continuation trial in the United States and Australia is expected as early as first quarter 2021. Novavax also recently completed enrollment of more than 15,000 volunteers in a Phase 3 trial of the candidate vaccine in the United Kingdom, which is also testing two injections of 5 mcg of protein and 50 mcg of Matrix-M adjuvant administered 21 days apart.
Phase 3 trial of Novavax investigational COVID-19 vaccine opens — https://www.nih.gov/news-events/news-releases/phase-3-trial-novavax-investigational-covid-19-vaccine-opens
Barry Lopez: On Art and Living Well — BREVITY’s Nonfiction Blog
The author Barry Lopez passed away on Christmas Day, and we will truly miss him. His sentences were beautiful, and he was as well: setting an example as an artist, a citizen, and a human being. Thankfully, he left us with so much of his wisdom and heart, including this passage, on the subject of […]
Barry Lopez: On Art and Living Well — BREVITY’s Nonfiction Blog
Ultraprocessed Food Again Linked to Increased CVD, Death
High consumption of UPF in this Mediterranean cohort was associated with a 58% increased risk for CVD mortality and 52% higher risk of dying from ischemic heart disease (IHD) and cerebrovascular causes, independently of known risk factors for CVD, even among individuals who otherwise adhered to the Mediterranean diet.
The foods that contributed most to total UPF consumed were processed meat, which accounted for 19.8% of UPF intake; pizza (16.8%); and cakes and pies (13.4%).
The researchers found a direct linear dose-response relation between a 5% increase in the proportion of UPF in the diet and risk for all-cause and CVD mortality.
Cite this: Ultraprocessed Food Again Linked to Increased CVD, Death – Medscape – Dec 24, 2020. — https://www.medscape.com/viewarticle/943200?src=rss
After reading the full summary of the study I had some issues with the study findings on pizza. Apparently I’m not alone. From the comment section:
Pizzas were mentioned by the authors and Dr. Walter Willet (for whom I have always had great admiration and consider him among my 3 most valued nutrition resources) as a UPF. However, even as a consistent follower of Mediterranean diet for >40 years, I see nothing wrong with occasional enjoyment of two or three slices of Margherita pizza (which is not covered with any processed meats or extra cheeses).
Dr. Michael Mogadam
Like I’ve said many, many times pizza is a food group and should not be considered an ultraprocessed food. Without pizza life would not be possible. Pass on the chips, sugary drinks, restructured meat (see https://www.sciencedirect.com/topics/food-science/restructured-meat) and other types of junk food.
Don’t pass on the pizza!
12.25.20
Hall Of Shame Showcases $80B Pandemic Of Insurance Fraud
WASHINGTON, Dec. 23, 2020 — Homeless New Yorkers are targeted in a $31.7 million slip-and-fall ring … A crime ring burns and floods dozens of homes. … A sober-home mogul trades sex for drugs.
Source: Hall Of Shame Showcases $80B Pandemic Of Insurance Fraud
N501Y mutation in SARS-CoV-2 virus causes increased infectivity, disease severity in mice — Science Chronicle
Chinese researchers found N501Y mutation in a mouse-adapted SARS-CoV-2 virus strain. In the mouse model, the N501Y mutation was found to increase the binding affinity of the virus with the mouse ACE2 receptor. The mutation in the mouse-adapted strain also caused increased virulence. In a preliminary report posted on December 19, Dr. Andrew Rambaut from […]
N501Y mutation in SARS-CoV-2 virus causes increased infectivity, disease severity in mice — Science Chronicle
Interesting article and the last paragraphs must be emphasized.
Dr. Gagandeep Kang, Professor of Microbiology at CMC Vellore, however, cautions that emergence of N501Y mutation has been seen on other occasions. According to her, the N501Y mutation in a strain that has been adapted to infect a mouse model cannot be compared with the N501Y mutation seen in the new variant infecting humans. And the severity of diseases caused by the mutation in the mouse model has no relevance to humans, she says.
“At this time, one can only say the mutation increases binding affinity in humans and hence increased transmissibility. Nothing can be said about disease severity,” says Dr. Kang.
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