Pumpkin Tree – 2021
Month: October 2021
Thinking About a Booster Shot?
The graph shows increases in the numbers of daily severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and new cases of severe coronavirus disease 2019 (Covid-19), on different scales, during the delta variant wave among persons who had received two doses of vaccine.
Waning Immunity after the BNT162b2 Vaccine in Israel – https://www.nejm.org/doi/full/10.1056/NEJMoa2114228?af=R&rss=currentIssue
It may be real nerdy but I like to do my research.
Higher Mortality Risk Among Transgender People
Transgender people have a 2-fold higher mortality risk than the general population, a study of about 4600 transgender people in the Netherlands reported.
Higher Mortality Risk Among Transgender People – https://jamanetwork.com/journals/jama/fullarticle/2785253
Don’t Take an Aspirin and Call Me in the Morning — A Country Doctor Writes:
People are asking about the latest US Public Health Service Taskforce on Prevention (USPSTF) recommendation about the use of aspirin to prevent heart disease. It has been a long-standing recommendation for people who already have heart disease. When I turned 50, I started taking a “baby” aspirin. That was their recommendation then. I stopped taking […]
Don’t Take an Aspirin and Call Me in the Morning — A Country Doctor Writes:
Personal Note:
A few years back I was taking 81mg aspirin AND fish oil. I stopped taking the fish oil because every nick, scratch and cut would not stop bleeding and took a long time to clot. Personally I plan on continuing my aspirin therapy at least until my next wellness exam. My physician wanted me to continue aspirin until age 70. We’ll see.
Molnupiravir 3.0
This post is updated to include a link to the http://www.nature.com article on this drug’s development history.
A planned interim analysis of 775 patients in Merck’s study found that 7.3% of those given molnupiravir were either hospitalized or had died by 29 days after treatment, compared with 14.1% of placebo patients. There were no deaths in the molnupiravir group, but there were eight deaths of placebo patients.
Merck to Seek FDA OK for Its COVID Pill After Trial Stopped Early — https://www.medscape.com/viewarticle/960089?src=rss#vp_2
What we know — and don’t know — about Merck’s new Covid-19 pill
https://www.statnews.com/2021/10/04/what-we-know-and-dont-know-about-mercks-new-covid-19-pill/?utm_campaign=rss
Molnupiravir, on the other hand, gets incorporated into burgeoning RNA strands and, once inside, wreaks havoc. The compound can shift its configuration, sometimes mimicking the nucleoside cytidine and sometimes mimicking uridine. Those RNA strands become faulty blueprints for the next round of viral genomes. Anywhere the compound gets inserted and that conformational shift happens, a point mutation occurs, Plemper says. When enough mutations accumulate, the viral population collapses. “That is what we term lethal mutagenesis,” he adds. “The virus essentially mutates itself to death.” And because the mutations accumulate randomly, it’s difficult for viruses to evolve resistance to molnupiravir — another plus for the compound. But the compound’s mutagenic potential in human cells — the possibility that it could incorporate itself into DNA — does raise safety concerns, some researchers say.
How antiviral pill molnupiravir shot ahead in the COVID drug hunt — https://www.nature.com/articles/d41586-021-02783-1
HEPA (high-efficiency particulate air) Filters and Covid-19 – Updated 10.10.21
Research at a hospital swamped by people with COVID-19 has confirmed that portable air filters effectively remove SARS-CoV-2 particles from the air — the first such evidence in a real-world setting1. The results suggest that air filters could be used to reduce the risk of patients and medical staff contracting SARS-CoV-2 in hospitals, the study’s authors say.
Real-world data show that filters clean COVID-causing virus from air — https://www.nature.com/articles/d41586-021-02669-2
We have several HEPA filters in the house to remove allergens for the allergy sufferer and now…
We have several HEPA filters in the house to remove SARS-CoV-2 virus from the house
The study findings have not been peer reviewed. But this won’t stop me from picking up one or two more HEPA’s for the house.
Update 10.10.21
Here’s a link to the http://www.nature.com podcast, same topic plus the Bangladesh mask study findings. Ten minute listen for those without the time to read the full article. https://www.nature.com/articles/d41586-021-02785-z
Molnupiravir 2.0
A planned interim analysis of 775 patients in Merck’s study found that 7.3% of those given molnupiravir were either hospitalized or had died by 29 days after treatment, compared with 14.1% of placebo patients. There were no deaths in the molnupiravir group, but there were eight deaths of placebo patients.
Merck to Seek FDA OK for Its COVID Pill After Trial Stopped Early — https://www.medscape.com/viewarticle/960089?src=rss#vp_2
What we know — and don’t know — about Merck’s new Covid-19 pill
https://www.statnews.com/2021/10/04/what-we-know-and-dont-know-about-mercks-new-covid-19-pill/?utm_campaign=rss
Take a Break 10.01.21
“I’m sick to death of people saying we’ve made 11 albums that sound exactly the same. In fact, we’ve made 12 albums that sound exactly the same.”
Angus Young, AC/DC
Molnupiravir
A planned interim analysis of 775 patients in Merck’s study found that 7.3% of those given molnupiravir were either hospitalized or had died by 29 days after treatment, compared with 14.1% of placebo patients. There were no deaths in the molnupiravir group, but there were eight deaths of placebo patients.
Merck to Seek FDA OK for Its COVID Pill After Trial Stopped Early — https://www.medscape.com/viewarticle/960089?src=rss#vp_2
lifeunderwriter.net 
You must be logged in to post a comment.