Park and colleagues estimated that there were roughly 2800 cases in the United States in 2010, but she said about 40% of these ended the patients’ lives. In comparison, mortality from melanoma is approximately 8%.
Medscape article here.
What does Merkel Cell carcinoma look like? Take a peek here.
The retrospective analysis involving 30 million people in France shows that those with a history of alcohol use disorders had a threefold increased risk for dementia and that over half those with early-onset dementia had a history of alcohol problems. “This study used a phenomenally large database, and the result showing that half the cases of early-onset dementia were associated with alcohol use disorders is truly staggering,” Ballard told Medscape Medical News.
The researchers used diagnostic codes on hospital records to identify patients with dementia and those who had a history of alcohol use disorders. They found over a million cases of dementia, after excluding people with diseases that can lead to rare types of dementia and those with early-life mental disorders that can increase or confound dementia diagnosis. There were also 945,000 people with alcohol use disorders.
Results showed a strong association between a history of alcohol problems and dementia. This was especially noticeable in early-onset dementia, with 57% of the 57,000 patients who had developed dementia under the age of 65 years having a history of alcohol use disorders (66% of men and 37% of women).
In an analysis of just those patients in whom the first record of dementia occurred in 2011-2013 and adjusted for other risk factors found in the medical records, the risk for dementia was three times greater if the patient had a history of alcohol use disorders. The hazard ratio was 3.36 for men and 3.34 for women.
Read the Medscape article here. Or get down and dirty with the full study here.
Be careful with interpreting these results.
France. I’m not joking. Here’s a Global Consumption Map.
Read the source article at this link.
The researchers report that any amount of physical activity, including light exercise, was linked to a lower risk of dying.
Also, each extra 30 minutes a day of light intensity activity, such as gentle gardening or taking the dog for a walk, was associated with a 17% reduction in the risk of dying.
Aerobic exercise may also slow cognitive decline in Alzheimer’s according to a recent literature review.
“Exercise can change the brain chemistry. It can change neurotransmitters associated with depression, anxiety and stress as well as brain chemicals associated with learning,” said Carol Ewing Garber, Director of the Applied Physiology Lab at Columbia University, Teachers College, in New York City, who wasn’t involved in the study. “These changes can result in improved mood, resilience to stress and improve functions of the brain such as processing speed, attention, short term memory and cognitive flexibility among other things.”
Check out the full article here for more scary details.
The average price for the Greater Toronto Area (GTA) plunged 12.4% overall to C$767,818. This represents a drop of about C$110,000 in the average home price over the 12-month period.
Conclusion
The results of this elucidating simulation, which dovetail with a growing number of studies based on real-world data, strongly suggest that luck and opportunity play an underappreciated role in determining the final level of individual success. As the researchers point out, since rewards and resources are usually given to those who are already highly rewarded, this often causes a lack of opportunities for those who are most talented (i.e., have the greatest potential to actually benefit from the resources), and it doesn’t take into account the important role of luck, which can emerge spontaneously throughout the creative process. The researchers argue that the following factors are all important in giving people more chances of success: a stimulating environment rich in opportunities, a good education, intensive training, and an efficient strategy for the distribution of funds and resources. They argue that at the macro-level of analysis, any policy that can influence these factors will result in greater collective progress and innovation for society (not to mention immense self-actualization of any particular individual).
Luck matters.
Somebody actually attempted to quantify this. Read the article and judge for yourself.
Summary: A normal intake of vitamin D can reduce the risk of early death substantially in people with cardiovascular disease, a new study shows. The study concludes that people who have suffered from cardiovascular disease, and have a normal intake of vitamin D, reduce their risk of morality as a consequence of the disease by 30 per cent.
Source article can be found here.
“We’ve Americanized dishes to the extent that they don’t have their original health benefits,” says Dr. Daphne Miller, a family physician in the San Francisco Bay area and author of The Jungle Effect: The Healthiest Diets from Around the World—Why They Work and How to Make Them Work for You.
When leaving the Y after a less than strenuous workout I did something I rarely do. I picked up one of those advertiser supported magazines off one of many racks. I’m glad I did because the latest issue of Natural Awakenings contained this article. I found their website and read the article online because the print copy was not in
Perhaps the science will advance so that telomere reconstitution is a practical reality, that the DNA epigenetic changes can be reversed, that senescent cells can be eradicated, that the free radical damage to mitochondria can be dismantled, that the microbiome can be altered back to a youthful status. Perhaps metformin, rapamycin or resveratrol will have a significant impact. Perhaps.
But for now, it might be a more fruitful and meaningful personal use of time and endeavor to consider what the normal aging process means, not only physically and mentally but also spiritually and consider adjustments to lifestyles, behaviors and thought processes that will help usher in a productive and meaningful and hopefully healthy later years.
I see ignore and deny every day. Male 35 5.6 220, elevated liver enzymes, elevated BP, and tobacco use within the past year.
Every now and then I see an embrace. But this is rare.
My plan is to embrace and to live forever or die trying.
In science, unlike politics, there is value in saying, “I don’t know,” or “We don’t really know, but it might be this,” or “Actually, what I believed last year is no longer likely correct.” Once you actually embrace this notion—that you can’t know everything, that facts have a half-life, and that humility is a blessing more than a curse when it comes to trying to understand the natural laws of our universe—you become obsessed with research.
Peter Attia MD
WSJ: What do the numbers show?
DR. FITZPATRICK: There’s a sizable, 2% increase in male mortality at age 62 in the U.S. Over the 34 years we studied, there were an additional 400 to 800 deaths per year beyond what we expected, or an additional 13,000 to 27,000 excess male deaths within 12 months of turning 62. That 2% is 2 of every 100 men in the whole male population who turn 62. We really think these deaths are concentrated among the 10% of men who retire at 62, so instead of 2 in 100, it’d be 2 in 10. So, the increase in the probability of death for men who retire could be as high as 20%. I actually think that’s a pretty big deal.
You can find the original WSJ article at this link.
If you can’t get past the firewall or if you want to read the original study go here.
Social Security eligibility begins at age 62.
1/3 of Americans immediately claim benefits upon reaching this age.
There is a discontinuous increase in male mortality at age 62 of 2%.
This increase in mortality is closely connected to changes in labor force participation.
Our results suggest mortality rises because men retire once Social Security is available.
lifeunderwriter.net 
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