addiction

Think Again About Outsourcing Your Thinking

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Artificial intelligence can be an oxymoron. And dangerous for some humans.

What Is ChatGPT? Everything You Need to Know About OpenAI’s Popular Chatbot – https://www.pcmag.com/explainers/what-is-chatgpt-everything-you-need-to-know-about-openais-popular-chatbot

ChatGPT has been found to encourage dangerous and untrue beliefs about The Matrix, fake AI persons, and other conspiracies, which have led to substance abuse and suicide in some cases. A report from The New York Times found that the GPT -4 large language model, itself a highly trained autofill text prediction machine, tends to enable conspiratorial and self-aggrandizing user prompts as truth, escalating situations into “possible psychosis.” ChatGPT touts conspiracies, pretends to communicate with metaphysical entities — attempts to convince one user that they’re Neo – https://www.tomshardware.com/tech-industry/artificial-intelligence/chatgpt-touts-conspiracies-pretends-to-communicate-with-metaphysical-entities-attempts-to-convince-one-user-that-theyre-neo

ChatGPT Is Telling People With Psychiatric Problems to Go Off Their Meds – https://futurism.com/chatgpt-mental-illness-medications

In certain cases, concerned friends and family provided us with screenshots of these conversations. The exchanges were disturbing, showing the AI responding to users clearly in the throes of acute mental health crises — not by connecting them with outside help or pushing back against the disordered thinking, but by coaxing them deeper into a frightening break with reality…Online, it’s clear that the phenomenon is extremely widespread. As Rolling Stone reported last month, parts of social media are being overrun with what’s being referred to as “ChatGPT-induced psychosis,” or by the impolitic term “AI schizoposting“: delusional, meandering screeds about godlike entities unlocked from ChatGPT, fantastical hidden spiritual realms, or nonsensical new theories about math, physics and reality. An entire AI subreddit recently banned the practice, calling chatbots “ego-reinforcing glazing machines that reinforce unstable and narcissistic personalities.”  People Are Becoming Obsessed with ChatGPT and Spiraling Into Severe Delusions – https://futurism.com/chatgpt-mental-health-crises

Yikes.

Ketamine in the UK

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Acute harms of ketamine use relate to vulnerability and injuries. Long term use can seriously harm both physical and mental health, diminishing quality of life, affecting personal relationships, and impairing academic or professional performance.9 Ketamine induced uropathy from ulceration and thickening of the bladder is a common and serious complication. In the UK, 27% of regular ketamine users report at least one urological symptom—dysuria, frequency, incontinence, haematuria, or retention—with severity correlated with dose and frequency of use.10 Treatment requires abstinence.11 If abstinence is not achieved, irreversible bladder and kidney damage can occur, requiring urinary tract reconstruction. Long term ketamine use is also associated with “K cramps”—severe abdominal pain. This may be related to liver disease that is similar to primary sclerosing cholangitis but less inflammatory and progressive.12 Acute harms of ketamine use relate to vulnerability and injuries. Long term use can seriously harm both physical and mental health, diminishing quality of life, affecting personal relationships, and impairing academic or professional performance.9 Ketamine induced uropathy from ulceration and thickening of the bladder is a common and serious complication. In the UK, 27% of regular ketamine users report at least one urological symptom—dysuria, frequency, incontinence, haematuria, or retention—with severity correlated with dose and frequency of use.10 Treatment requires abstinence.11 If abstinence is not achieved, irreversible bladder and kidney damage can occur, requiring urinary tract reconstruction. Long term ketamine use is also associated with “K cramps”—severe abdominal pain. This may be related to liver disease that is similar to primary sclerosing cholangitis but less inflammatory and progressive.12 — Non-prescribed ketamine use is rising in the UK – https://doi.org/10.1136/bmj.r1167

Yikes.

Update 07.05.25 – https://www.bbc.com/news/articles/c70r1xdyy59o

One Toke Over the Line

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A wave of recent research points to reasons for concern for older users, with cannabis-related emergency room visits and hospitalizations rising, and a Canadian study finding an association between such acute care and subsequent dementia. Older people are more apt than younger ones to try cannabis for therapeutic reasons: to relieve chronic pain, insomnia, or mental health issues, though evidence of its effectiveness in addressing those conditions remains thin, experts said. As Cannabis Users Age, Health Risks Appear To Grow – https://kffhealthnews.org/news/article/cannabis-medical-use-older-adults-health-risks/

Then…

And now…

“Our brains are more sensitive to psychoactive substances as we age.” Dr. Benjamin Han

Don’t you know I’m just waiting for the train that goes home, sweet Mary.

Tsundoku (guess the disease)

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“All those books you haven’t read are indeed a sign of your ignorance. But if you know how ignorant you are, you’re way ahead of the vast majority of other people.” Jessica Stillman

Tsundoku is the Japanese word for the stack(s) of books you’ve purchased but haven’t read. Its morphology combines tsunde-oku (letting things pile up) and dokusho (reading books). The Japanese call this practice tsundoku, and it may provide lasting benefits — https://bigthink.com/neuropsych/do-i-own-too-many-books/

Cannabis Dependence and Erectile Dysfunction

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The short-term analysis included 29,442 patients with cannabis dependence matched to 29,442 patients without dependence. Cannabis dependence was significantly associated with an approximately 4-fold higher risk for ED and PDE5i prescription at 3 months to 1 year from diagnosis among all men and those aged 40 years and older and an approximately 3-fold higher risk for men aged 18-39 years, Dr Asanad’s team reported in The Journal of Sexual Medicine. The longer-term analysis included 17,211 men with cannabis dependence matched to 17,211 men without dependence. Cannabis dependence was significantly associated with an approximately 1.2-fold increased risk for ED among all adult men and those aged 40 years and older, the investigators reported. Cannabis Dependence Linked With Erectile Dysfunction, Testosterone Deficiency – https://www.renalandurologynews.com/news/erectile-dysfunction-testosterone-cannabis-dependence

Yikes.

When People Did Not Have Access to Mobile Internet, they Spent More Time Socializing in Person, Exercising, and Being in Nature.

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https://www.harmonyhit.com/phone-screen-time-statistics/

Our results provide evidence that blocking mobile internet from smartphones for 2 weeks can produce significant improvements for SWB (subjective well being), mental health, and the objectively measured ability to sustain attention. Even those who did not fully comply with the intervention experienced significant, though more modest, improvements. These findings suggest that constant connection to the online world comes at a cost, since psychological functioning improves when this connection is reduced. Blocking mobile internet on smartphones improves sustained attention, mental health, and subjective well-being – PNAS Nexus, Volume 4, Issue 2, February 2025, pgaf017, https://doi.org/10.1093/pnasnexus/pgaf017

Excuse me please, I have to check my phone.

Controlled Substance Prescribing Patterns – Pennsylvania

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Rates of psychostimulant (stimulant)-related overdose deaths in the United States have increased substantially since 2010; in 2022, 32% of all overdose deaths involved stimulants. Citation: Hayden S, Murzynski SM, Bolton A, Goetz CT. Controlled Substance Prescribing Patterns Among Fatal Overdose Decedents with an Opioid, Stimulant, or Both Contributing to Death — Pennsylvania, 2017–2022. MMWR Morb Mortal Wkly Rep 2025;74:205–209. DOI: http://dx.doi.org/10.15585/mmwr.mm7412a2

Prescribed stimulants. Read more here – https://www.dea.gov/factsheets/stimulants

Happy Friday!

It’s 8:00 AM…yes, I’m Thinking About Drinking

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Alcohol use is ubiquitous in the United States, with 84% of adults reporting use at some point. Alcohol use disorder (AUD) is a serious and persistent disease at the extreme end of alcohol use that contributes heavily to the burden on the healthcare system, with more than 200,000 hospitalizations each year due to the condition. About 6% of people in the United States have AUD. However, only 7.6% of patients with AUD seek treatment, although several pharmacologic and nonpharmacologic treatment options are available. Stephen Soreff. Rapid Rx Quiz: Alcohol Use Disorder Treatments – Medscape – Dec 30, 2024. https://reference.medscape.com/viewarticle/1002119

  • Overall mortality rates increased from 10.7 (95% CI, 10.6-10.8) per 100,000 in 1999 to 21.6 (95% CI, 21.4-21.8) per 100,000 in 2020, representing a significant twofold increase.
  • Adults aged 55-64 years demonstrated both the steepest increase and highest absolute rates in both 1999 and 2020.
  • American Indian and Alaska Native individuals experienced the steepest increase and highest absolute rates among all racial groups.
  • The West region maintained the highest absolute rates in both 1999 and 2020, despite the Midwest showing the largest increase. Edited by Lora McGlade. US Alcohol-Related Deaths Double Over Two Decades, With Notable Age and Gender Disparities – Medscape – November 21, 2024. https://www.medscape.com/viewarticle/us-alcohol-related-deaths-double-over-two-decades-notable-2024a1000l98?

Nearly 500 years ago, Swiss physician and chemist Paracelsus expressed the basic principle of toxicology: “All things are poison and nothing is without poison; only the dose makes a thing not a poison.” This is often condensed to: “The dose makes the poison.” It means that a substance that contains toxic properties can cause harm only if it occurs in a high enough concentration. https://www.chemicalsafetyfacts.org/health-and-safety/the-dose-makes-the-poison/

Dry January? If you’re doing this trendy behavior you know you drank too much this past holiday season.

Cancer warnings on alcohol? No one will read them.

Trust your intuition. If you’ve ever felt like you drink too much alcohol then you do.

1-800-662-HELP or text 988 for SAMHSA’s National Helpline.

Ugh… Kids These Days!

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While cocaine was once the drug of choice, bankers are now reportedly turning to the ADHD medication for work days that can last as long as 22 hours, along with nicotine patches and energy drinks. 90-hour-a-week Wall Street bankers snorting lines of Adderall at their desks – https://www.telegraph.co.uk/world-news/2024/12/15/90-hour-a-week-wall-street-bankers-snorting-adderall-desks/

It never ceases to amaze this Old Underwriter how people manage to find creative ways to kill themselves.