Mental Health

Social isolation and Lower Brain Volume

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The people with the lowest amount of social contact had overall brain volume that was significantly lower than those with the most social contact. The total brain volume, or the sum of white and grey matter, as a percentage of the total intracranial volume, or the volume within the cranium, including the brain, meninges, and cerebrospinal fluid, was 67.3% in the lowest contact group compared to 67.8% in the highest contact group. They also had lower volumes in areas of the brain such as the hippocampus and amygdala that play a role in memory and are affected by dementia.

The study does not prove that social isolation causes brain shrinkage; it only shows an association.

Social isolation linked to lower brain volume — American Academy of Neurology. “Social isolation linked to lower brain volume.” ScienceDaily https://www.sciencedaily.com/releases/2023/07/230712165229.htm (accessed July 13, 2023).

Yikes!

Take Your Vitamins

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In the current study, more than 3,500 adults (mostly non-Hispanic white) over age 60 were randomly assigned to take a daily multivitamin supplement or placebo for three years. At the end of each year, participants performed a series of online cognitive assessments at home designed to test memory function of the hippocampus, an area of the brain that is affected by normal aging. The COSMOS-Web study is part of a large clinical trial led by Brigham & Women’s Hospital and Harvard called the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).

By the end of the first year, memory improved for people taking a daily multivitamin, compared with those taking a placebo. The researchers estimate the improvement, which was sustained over the three-year study period, was equivalent to about three years of age-related memory decline. The effect was more pronounced in participants with underlying cardiovascular disease.

Columbia University Irving Medical Center. “Multivitamin improves memory in older adults, study finds.” ScienceDaily. http://www.sciencedaily.com/releases/2023/05/230524181916.htm (accessed May 25, 2023).

(I am) Flunking Retirement

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Participants with the most positive views of aging were living, on average, 7.5 years longer than those with the most negative views. 90%: the percentage of centenarians who were functionally independent in their 90’s.

People who live long lives can teach us how to live healthy lives.

Flunking Retirement – https://ysph.yale.edu/about-school-of-public-health/communications-public-relations/publications/public-health-magazine/article/flunking-retirement/

The source article is an interview with two Yale alumni who are still working at the age of 82. Both are youngsters when compared to…Willie who just turned 90 and still working.

Take a Break – 04.19.23 (let’s do some brain remodeling)

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A study led by the UNIGE, HES-SO Geneva, and EPFL revealed that music practice and active listening could prevent working memory decline. Such activities promoted brain plasticity, they were associated with grey matter volume increase. Positive impacts have also been measured on working memory. This study was conducted among 132 healthy retirees from 62 to 78 years of age. One of the conditions for participation was that they had not taken any music lessons for more than six months in their lives…The participants were randomly assigned to two groups, regardless of their motivation to play an instrument. The second group had active listening lessons, which focused on instrument recognition and analysis of musical properties in a wide range of musical styles. The classes lasted one hour. Participants in both groups were required to do homework for half an hour a day.”

After six months, we found common effects for both interventions. Neuroimaging revealed an increase in grey matter in four brain regions involved in high-level cognitive functioning in all participants, including cerebellum areas involved in working memory. Their performance increased by 6% and this result was directly correlated to the plasticity of the cerebellum,” says Clara James, last author of the study, a privat-docent at the Faculty of Psychology and Educational Sciences of UNIGE, and full professor at the Geneva School of Health Sciences

Université de Genève. “How music can prevent cognitive decline.” ScienceDaily. http://www.sciencedaily.com/releases/2023/04/230417142520.htm (accessed April 18, 2023).

Journal Reference – Damien Marie, Cécile A.H. Müller, Eckart Altenmüller, Dimitri Van De Ville, Kristin Jünemann, Daniel S. Scholz, Tillmann H.C. Krüger, Florian Worschech, Matthias Kliegel, Christopher Sinke, Clara E. James. Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy. Neuroimage: Reports, 2023; 3 (2): 100166 DOI: 10.1016/j.ynirp.2023.100166

I could feel my brain grey matter volume increasing when listening to this album.

People who think positively about aging are more likely to recover memory

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A new study has found that older persons with mild cognitive impairment (MCI), a common type of memory loss, were 30% more likely to regain normal cognition if they had taken in positive beliefs about aging from their culture, compared to those who had taken in negative beliefs.

Yale School of Public Health. “People who think positively about aging are more likely to recover memory.” ScienceDaily. http://www.sciencedaily.com/releases/2023/04/230412131116.htm (accessed April 18, 2023).

Journal Reference – Becca R. Levy, Martin D. Slade. Role of Positive Age Beliefs in Recovery From Mild Cognitive Impairment Among Older Persons. JAMA Network Open, 2023; 6 (4): e237707 DOI: 10.1001/jamanetworkopen.2023.7707

I cannot believe how wonderful the aging process is said no one ever.

Depression and Accelerated Biological Aging

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“These patients show evidence of accelerated biological aging, and poor physical and brain health,” which are the main drivers of this association, says Breno Diniz, a UConn School of Medicine geriatric psychiatrist and author of the study, which appears in Nature Mental Health on March 22.

Diniz and colleagues from several other institutions looked at 426 people with late-in-life depression. They measured the levels of proteins associated with aging in each person’s blood. When a cell gets old, it begins to function differently, less efficiently, than a “young” cell. It often produces proteins that promote inflammation or other unhealthy conditions, and those proteins can be measured in the blood. Diniz and the other researchers compared the levels of these proteins with measures of the participants’ physical health, medical problems, brain function, and the severity of their depression.

University of Connecticut. “Depressed, and aging fast: Older adults with late-in-life-depression age biologically older than their chronological peers..” ScienceDaily. http://www.sciencedaily.com/releases/2023/03/230322190947.htm (accessed March 25, 2023).

Journal Reference:

Johanna Seitz-Holland, Benoit H. Mulsant, Charles F. Reynolds III, Daniel M. Blumberger, Jordan F. Karp, Meryl A. Butters, Ana Paula Mendes-Silva, Erica L. Vieira, George Tseng, Eric J. Lenze, Breno S. Diniz. Major depression, physical health and molecular senescence markers abnormalities. Nature Mental Health, 2023; 1 (3): 200 DOI: 10.1038/s44220-023-00033-z

Troubling Trends

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Early adolescence is characterized by wide-reaching hormonal changes, as well as physiological changes throughout the body. At the same time, all sorts of neural, cognitive and social shifts are happening. These changes could make social-media environments, such as those provided by Snapchat or TikTok, particularly alluring, but also especially impactful on mental health9–11. Several developmental-psychology studies have shown, for instance, that adolescents — particularly those in early to mid-adolescence — place increased importance on being able to interact with their peers, and on what their peers think of them12. Other studies suggest that although young children tend to view themselves positively, as they become adolescents, their ideas about themselves come to more closely align with what they perceive others to think of them13,14. Still more work has shown that being rejected or not being included has a greater impact on mood for those in early to mid-adolescence than for people older than 2515.

How social media affects teen mental health: a missing link — Nature 614, 410-412 (2023) — https://www.nature.com/articles/d41586-023-00402-9

I Thought I Told You To Put That Phone Down!

If I have to tell you one more time to Put The Phone Away…

Yikes!

Reefer Madness

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Violence associated with psychosis has also been well-documented. Marijuana use may be associated with increased impulsivity on the same day and the following day relative to days when marijuana was not used. It is also associated with increased hostile behaviors and perceptions of hostility in others on the same day compared to days when marijuana was not used. Cannabis use disorder appears to increase the risk of aggression towards others, particularly among youths. There is also evidence of a moderate association between cannabis use and physical violence.

Psychosis can be caused by various conditions, including licit and illicit substances, particularly cannabis. Cannabis has a higher conversion rate to psychosis than other substances. 32 percent of patients with substance-induced psychosis convert to either bipolar or schizophrenia-spectrum disorders, with the highest conversion rate found with cannabis-induced psychosis (47 percent). There is debate about the causal relationship between cannabis and psychosis. However, this can be demonstrated using Bradford-Hill criteria. Despite this, psychosis is often multifactorial in many instances. Cannabis exposure increases the risk of psychosis, from transient psychotic states to chronic recurrent psychosis. In individuals with established psychosis, cannabis has a negative impact on the course and expression of the illness.

The dark side of cannabis: increased risk of psychosis — https://www.kevinmd.com/2023/01/the-dark-side-of-cannabis-increased-risk-of-psychosis.html

But really, Does Marijuana Have Any Bad Side Effects?

You must be joking about Cannabis and Psychosis, right?

Marijuana and hallucinogen use among young adults reached all-time high in 2021

Marijuana Tied to Ongoing, Subclinical Psychosis in Teens