The researchers put mice on a diet and assessed which circuits in the brain changed. In particular, they examined a group of neurons in the hypothalamus, the AgRP neurons, which are known to control the feeling of hunger. They were able to show that the neuronal pathways that stimulate AgRP neurons sent increased signals when the mice were on a diet. This profound change in the brain could be detected for a long time after the diet.
Max Planck Institute for Biology of Ageing. “Dieting: Brain amplifies signal of hunger synapses: Possible target for drugs to combat the yo-yo effect.” ScienceDaily. http://www.sciencedaily.com/releases/2023/03/230324135218.htm (accessed March 28, 2023).
A study by the World Obesity Foundation predicts that more than half the global population will be living with overweight and obesity within 12 years if prevention, treatment and support do not improve.
The picture above is a normal size slice at Benny’s. The tall beer can was strictly in the picture to provide perspective. For more about Benny’s see https://garyskitchen.net/worship-the-whale/.
CONCLUSIONS: The 2-part models of instrumental variables, which estimate the causal effects of obesity on direct medical costs, showed that the effect of obesity is greater than suggested by previous studies, which estimated only correlations. Much of the aggregate national cost of obesity—$260.6 billion—represents external costs, providing a rationale for interventions to prevent and reduce obesity.
Strong, consistent evidence shows that managing obesity can delay progression of prediabetes to type 2 diabetes. Obesity management is also highly beneficial in treating type 2 diabetes, based on the degree of weight loss achieved. Losing excess weight improves glycemic control, reduces the need for glucose-lowering medications, can substantially reduce A1C, and can even promote sustained diabetes remission.
Increased consumption of ultraprocessed foods (UPFs) was associated with more than 10% of all-cause premature, preventable deaths in Brazil in 2019. That is the finding of a new peer-reviewed study in the American Journal of Preventive Medicine.
Examples of UPFs are prepackaged soups, sauces, frozen pizza, ready-to-eat meals, hot dogs, sausages, sodas, ice cream, and store-bought cookies, cakes, candies and doughnuts.
UPFs have steadily replaced the consumption of traditional whole foods, such as rice and beans, in Brazil.
The skeptical cardiologist was asked to give a lecture in July on diet to the cardiology fellows in our training program at Saint Louis University. Needless to say, I didn’t hew to current recommendations from the American Heart Association or the Dietary Guidelines for Americans. For example, these recommendations are still promoting the narrative that…
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