GLP-1s and the Risk for Malnutrition

“We see cases where people take a GLP-1 medication and become so severely malnourished that they need to be hospitalized,” said Rebecca Boswell, PhD, director of Penn Medicine Princeton Center for Eating Disorders, in Philadelphia. “It’s not uncommon.” The Scary Health Risk That Can Sneak Up on GLP-1 Users – Medscape – January 19, 2026. https://www.medscape.com/viewarticle/scary-health-risk-can-sneak-glp-1-users-2026a10001pi

Yikes.

People return to their baseline weight and lose all cardiometabolic benefits in less than 2 years after stopping semaglutide or tirzepatide, a new meta-analysis found. Weight Regain, Health Benefit Loss Rapid When GLP-1s Stopped – Medscape – January 08, 2026. https://www.medscape.com/viewarticle/weight-regain-health-benefit-loss-rapid-when-glp-1s-stopped-2026a10000kr?

YIKES.

You see, cures are passée. Cures kill markets. Getting the population properly hooked on a pharmaceutical treatment for a ‘chronic’ condition is where the serious money is. “Our core insight was simple and grim: it’s far easier—and infinitely more profitable—to convince healthy people that they’re sick than to develop genuine cures for the truly ill.

Twenty years later, the hustle is bigger, slicker, and more dangerous than ever. Watching that hustle unfold with weight loss drugs feels weirdly ominous, like watching a slow-moving train wreck you can’t peel your eyes off of. You know there’ll be carnage and bodies, vast fortunes won and lost, and humanity left just a little bit poorer. We have often documented the pharmaceutical industry’s proven ability to create enormously lucrative markets overnight, by inventing and selling diseases. Now watch as all that ingenuity and energy gets pointed at one of the biggest problems bewitching humanity: human fatness. The Seven Deadly Sins of Weight Loss Drugshttps://brownstone.org/articles/the-seven-deadly-sins-of-weight-loss-drugs/

YIKES!

This will not end well.

Complications? What Complications? (just another GLP-1 receptor agonist post)

Now READ THIS (if you can)

Just a few days ago I posted READ THIS! (if you can). Then I came across this:

A conservative colleague said the use of AI to create addiction and device dependency was evil. That is an understatement. These kids rely on ChatGPT not just for information but also to make choices, and for many, that seems to extend to every aspect of their lives. Sam Altman makes clear in video clips below that this extreme loss of independence, of personal autonomy, is deliberate.

That means unless these kids can find a way to break free, they are cognitive serfs that can be told to do anything. How to vote. Whether to sign up to die in a hopeless war. Whether to take a job in a unsafe meatpacking plant and risk loss of limbs.

This widespread abuse is far worse than what the Sacklers and other opioid peddlers did to mainly working class pain victims, or what the British did to China in the Opium Wars. At least with opioid addiction, it is possible for the victims to recover even if the withdrawal process is painful. The evidence is mounting that even for adults, regular use of AI diminishes reasoning skills and attention spans.

These children are being turned into automatons, incapable of independent thought and action. It’s widely known in developmental psychology that if certain patterning does not happen at critical ages, the deficit is permanent. Kittens needing visual input in their first few days or they are blind. Kids who don’t crawl having coordination issues as adults due to missing important movement patterning. Less dramatic versions are not being able to make sounds in foreign languages if you have not heard and practiced them when young.

These young AI addicts are set to be permanently damaged. This is tech bros creating something as permanent and harmful as fetal alcohol syndrome on a mass basis. And they clearly know what they are doing, witness how they raise their children on completely different lines. “We Are Watching Critical Thinking Disappear in Real Time” Due to AI Addiction: 40% of Kids Can’t Read, Teachers Quitting in Droveshttps://www.nakedcapitalism.com/2026/01/we-are-watching-critical-thinking-disappear-in-real-time-due-to-ai-addiction-40-of-kids-cant-read-teachers-quitting-in-droves.html

Thanks for sharing Yves. But as one of your readers noted,

If we teach kids to think they won’t do what they’re told!

My Statin Comes From India

According to the USP, the bulk of the APIs come from India. That country is responsible for 50% of the active pharmaceutic ingredients. China is not far behind at 32%. The European Union supplies 10%. That’s a big change since 2000. Back then, European countries like France, Germany, Switzerland and Denmark supplied 42% of the APIs. Drug Recalls From India – Can You Trust Foreign-Made Generics?https://www.peoplespharmacy.com/articles/more-drug-recalls-from-india-do-you-trust-foreign-made-generics

Dozens of companies received approval from the FDA over the years to sell metoprolol and bupropion in the U.S. Yet from 2018 to 2024, the agency reported running only 2 tests on metoprolol and 7 on bupropion through its quality surveillance program — in each case, by pulling a sample from a single drug maker. In many of those years, the drugs weren’t tested at all, FDA records show. Those that were assessed received passing results. The FDA Often Doesn’t Test Generic Drugs for Quality Concerns, So ProPublica Didhttps://www.propublica.org/article/fda-generic-drug-testing

ClinCalc DrugStats Databasehttps://clincalc.com/DrugStats/

Both articles are long reads but worth your time.

Yikes.

Scary Charts – 12.04.25

Through November, employers have announced 1,170,821 job cuts, an increase of 54% from the 761,358 announced in the first eleven months of last year. Year-to-date job cuts are at the highest level since 2020 when 2,227,725 cuts were announced through November. It is the sixth time since 1993 that job cuts through November have surpassed 1.1 million. Challenger Report: 71,321 Job Cuts on Restructurings, Closings, Economy https://www.challengergray.com/blog/challenger-report-71321-job-cuts-on-restructurings-closings-economy/

Yikes.

In my less than illustrious career I’ve suffered 100% reductions in income multiple times. Hopefully the newly unemployed have some form of a fallback plan.

Stay safe. It’s fugly out there.

Not Your Grandma’s Teddy Bear

Safety features or not, it seems like the chatbots in these toys can be manipulated into engaging in conversation inappropriate for children. The consumer advocacy group U.S. PIRG tested a selection of AI toys and found that they are capable of doing things like having sexually explicit conversations and offering advice on where a child can find matches or knives. They also found they could be emotionally manipulative, expressing dismay when a child doesn’t interact with them for an extended period. Earlier this week, FoloToy, a Singapore-based company, pulled its AI-powered teddy bear from shelves after it engaged in inappropriate behavior. Do Not, Under Any Circumstance, Buy Your Kid an AI Toy for Christmashttps://gizmodo.com/do-not-under-any-circumstance-buy-your-kid-an-ai-toy-for-christmas-2000689652

AI-Powered Teddy Bear Caught Talking About Sexual Fetishes and Instructing Kids How to Find Kniveshttps://gizmodo.com/ai-powered-teddy-bear-caught-talking-about-sexual-fetishes-and-instructing-kids-how-to-find-knives-2000687140

The alleged perpetrator

Would You Trust an AI Chatbot with Your Children?

All this offloading of parental responsibility to AI is alarming because one of ChatGPT’s biggest flaws, its manipulative and sycophantic nature, is known to intensify delusions and cause breaks from reality — a grim phenomenon that’s been linked to numerous suicides, including several teenagers. Parents Using ChatGPT to Rear Their Childrenhttps://futurism.com/artificial-intelligence/parents-chatgpt-rear-children

Here’s the disclaimer from the ChatGPT homepage:

ChatGPT can make mistakes. Check important info.

Yikes.

Think Again About Outsourcing Your Thinking 2.0 (if you can)

Michael Gerlich, head of the Centre for Strategic Corporate Foresight and Sustainability at SBS Swiss Business School, began studying the impact of generative AI on critical thinking because he noticed the quality of classroom discussions decline. Sometimes he’d set his students a group exercise, and rather than talk to one another they continued to sit in silence, consulting their laptops. He spoke to other lecturers, who had noticed something similar. Gerlich recently conducted a study, involving 666 people of various ages, and found those who used AI more frequently scored lower on critical thinking. (As he notes, to date his work only provides evidence for a correlation between the two: it’s possible that people with lower critical thinking abilities are more likely to trust AI, for example.) Like many researchers, Gerlich believes that, used in the right way, AI can make us cleverer and more creative – but the way most people use it produces bland, unimaginative, factually questionable work. Are we living in a golden age of stupidity?https://www.theguardian.com/technology/2025/oct/18/are-we-living-in-a-golden-age-of-stupidity-technology

Yikes.

Antidepressant Prescriptions Increase 130% for Teenage Girls

The increasing rate of mental health disorders among children and adolescents is a concerning trend that has been observed for several decades, with survey studies revealing dramatic increases in anxiety, depression, and suicidal ideation.1 In the United States, suicide ranks as the second leading cause of death for those aged 10 to 19 years and the third leading cause of death for those aged 15 to 24 years.2 Antidepressant Prescriptions and Mental Healthhttps://publications.aap.org/pediatrics/article/153/3/e2023064677/196661/Antidepressant-Prescriptions-and-Mental-Health

Between January 2016 and December 2022, the monthly antidepressant dispensing rate increased 66.3%, from 2575.9 to 4284.8. Before March 2020, this rate increased by 17.0 per month (95% confidence interval: 15.2 to 18.8). The COVID-19 outbreak was not associated with a level change but was associated with a slope increase of 10.8 per month (95% confidence interval: 4.9 to 16.7). The monthly antidepressant dispensing rate increased 63.5% faster from March 2020 onwards compared with beforehand. In subgroup analyses, this rate increased 129.6% and 56.5% faster from March 2020 onwards compared with beforehand among females aged 12 to 17 years and 18 to 25 years, respectively. In contrast, the outbreak was associated with a level decrease among males aged 12 to 17 years and was not associated with a level or slope change among males aged 18 to 25 years. Antidepressant Dispensing to US Adolescents and Young Adults: 2016–2022https://publications.aap.org/pediatrics/article/153/3/e2023064245/196655/Antidepressant-Dispensing-to-US-Adolescents-and?autologincheck=redirected

Between 2020 and 2022, antidepressant prescriptions for girls aged 12-17 skyrocketed by 130%. Antidepressants Increase 130% for Teen Girls, Drop 7% For Boyshttps://brownstone.org/articles/antidepressants-increase-130-for-teen-girls-drop-7-for-boys/

Yikes.

Think Some More About Outsourcing Your Thinking (if you can)

Artificial Intelligence Breeds Mindless Inhumanity

By Bruce Abramson

July 15, 2025

I began studying AI in the mid-1980s. Unusually for a computer scientist of that era, my interest was entirely in information, not in machines. I became obsessed with understanding what it meant to live during the transition from the late Industrial Age to the early Information Age.  

What I learned is that computers fundamentally alter the economics of information. We now have inexpensive access to more information, and to higher quality information, than ever before. In theory, that should help individuals reach better decisions, organizations devise improved strategies, and governments craft superior policies. But that’s just a theory. Does it? 

The answer is “sometimes.” Unfortunately, the “sometimes not” part of the equation is now poised to unleash devastating consequences. 

Consider the altered economics of information: Scarcity creates value. That’s been true in all times, in all cultures, and for all resources. If there’s not enough of a resource to meet demand, its value increases. If demand is met and a surplus remains, value plummets.  

Historically, information was scarce. Spies, lawyers, doctors, priests, scientists, scholars, accountants, teachers, and others spent years acquiring knowledge, then commanded a premium for their services.  

Today, information is overabundant. No one need know anything because the trusty phones that never leave our sides can answer any question that might come our way. Why waste your time learning, studying, or internalizing information when you can just look it up on demand? 

Having spent the past couple of years working in higher education reform and in conversation with college students, I’ve come to appreciate the power—and the danger—of this question. Today’s students have weaker general backgrounds than we’ve seen for many generations because when information ceased being scarce, it lost all value.  

It’s important to recall how recently this phenomenon began. In 2011, an estimated one-third of Americans, and one-quarter of American teenagers, had smartphones. From there, adoption among the young grew faster than among the general population. Current estimates are that over 90% of Americans, and over 95% of teenagers, have smartphone access. 

Even rules limiting classroom use cannot overcome the cultural shift. Few of today’s college students or recent grads have ever operated without the ability to scout ahead or query a device for information on an as-needed basis. There’s thus no reason for them to have ever developed the discipline or the practices that form the basis for learning.

The deeper problem, however, is that while instant lookup may work well for facts, it’s deadly for comprehension and worse for moral thinking.

A quick lookup can list every battle of WWII, along with casualty statistics and outcome. It cannot reveal the strategic or ethical deliberations driving the belligerents as they entered that battle. Nor can it explain why Churchill fought for the side of good while Hitler fought for the side of evil—a question that our most popular interviewers and podcasters have recently brought to prominence. 

At least, lookup couldn’t provide such answers until recently. New AI systems—still less than three years old—are rushing to fill that gap. They already offer explanations and projections, at times including the motives underlying given decisions. They are beginning to push into moral judgments. 

Of course, like all search and pattern-matching tools, these systems can only extrapolate from what they find. They thus tend to magnify whatever is popular. They’re also easy prey for some of the most basic cognitive biases. They tend to overweight the recent, the easily available, the widely repeated, and anything that confirms pre-conceived models. 

The recent reports of Grok regurgitating crude antisemitic stereotypes and slogans illustrate the technological half of the problem. The shocking wave of terror-supporting actions wracking college campuses and drawing recent grads in many of our cities illustrate the human half. 

The abundance of information has destroyed its value. Because information—facts and data—are the building blocks upon which all understanding must rest, we’ve raised a generation incapable of deep understanding. Because complex moral judgments build upon comprehension, young Americans are also shorn of basic morality 

We are rapidly entering a world in which widespread access to voluminous information is producing worse—not better—decisions and actions at all levels. We have outsourced knowledge, comprehension, and judgment to sterile devices easily biased to magnify popular opinion. We have bred a generation of exquisitely credentialed, deeply immoral, anti-intellectuals on the brink of entering leadership. 

When the ubiquity of instant lookup evolves beyond basic facts and into moral judgments, banal slogans and mindless cruelty will come to rule our lives.  

Is there a way out of this morass?  Perhaps the only one that the ancients discovered back when information, understanding, and morality all retained immense value: faith in a higher power. Because the path we’ve set on our own is heading into some very dark places. 

This article was originally published by RealClearScience and made available via RealClearWire.