Scary Charts 05.17.26

Source – The Class of 2026 is cooked https://www.semafor.com/article/05/15/2026/ai-has-contorted-the-job-market-for-twentysomethings-leaving-college-this-may

Sourcehttps://layoffs.fyi/

“I think the junior level is definitely finding it harder now to enter the workforce,” said John Romeo, who leads the consulting firm’s research arm, the Oliver Wyman Forum. “It’s those mid- and senior-level employees that CEOs are now looking at to drive productivity.” That’s because of the types of tasks that AI agents are able to perform, from writing code at the level of a junior developer to evaluating sales leads. What the agents can’t do in many fields is make judgment calls using the insight that comes from on-the-job experience, according to labor experts. AI Poised to Tilt Job Market Leverage Toward Older Workershttps://finance.yahoo.com/economy/policy/articles/ai-poised-tilt-job-market-150000094.html

Yikes!

If you managed to scroll down this far here’s a bonus video.

Optimize This!

But the productivity gurus were child’s play compared to the rise of the biohacking movement that followed. Guys like Andrew Huberman and Bryan Johnson rose to fame in recent years with their strict diets, excessive supplementation, and elaborate morning routines. Science-backed exercise and nutrition advice became the name of the game. And there was no shortage of influencers to supply it. Optimizing Ourselves to Deathhttps://ofdollarsanddata.com/optimizing-ourselves-to-death/

You can’t optimize everything. Mistakes will be made and are part of life. Sub-optimal for whatever you are chasing will be the end result because perfection is impossible.

Tell yourself this is OK.

Peptides Explained

Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls.

The people currently using these compounds are, in effect, running an uncontrolled experiment on themselves. Peptides, explained: Answers to your top questionshttps://yourlocalepidemiologist.substack.com/p/peptides-explained-answers-to-your?

An uncontrolled experiment on themselves.

Yikes.

“Medical” Advice for the Masses

The AIs’ failure rates exceeded 80 percent when provided with given ambiguous symptoms that could match more than one condition, and for more straightforward cases that included including physical exam findings and lab results, they still failed 40 percent of the time. The researchers also found that unlike human clinicians, the “LLMs collapse prematurely onto single answers,” resulting in “weak performance” across all models. Millions of Americans Are Talking to AI Instead of Going to the Doctor, and It’s Giving Them Horrendously Flawed Medical Advicehttps://futurism.com/artificial-intelligence/millions-americans-ai-instead-doctor-bad-advice

Wow.

From the study discussion section:

Our evaluation suggests that despite rapid advances in pattern recognition and knowledge retrieval, current LLMs still lack the reasoning processes needed for safe clinical use. The consistent gap between differential diagnosis and final diagnosis highlights how differently these systems process information compared with physicians. Clinicians preserve uncertainty and iteratively refine differential diagnoses, whereas LLMs collapse prematurely onto single answers, a limitation that persists across model generations. Their weak performance on differential diagnosis, consistent with a prior study from authors of the current work,8 suggests these limitations persist across early and state-of-the-art models. The risk is not just that LLMs are sometimes wrong but that their reasoning is brittle precisely where uncertainty and nuance matter most. Benchmarks that reward only correct final answers risk reinforcing this shortcutting, widening the gap between marketing claims and the skills actually required at the bedside. Large Language Model Performance and Clinical Reasoning Tasks – Rao AS, Esmail KP, Lee RS, et al. Large Language Model Performance and Clinical Reasoning Tasks. JAMA Netw Open. 2026;9(4):e264003. doi:10.1001/jamanetworkopen.2026.4003 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2847679

Wow.

Should you really trust health advice from an AI chatbot? https://www.bbc.com/news/articles/clyepyy82kxo. Dr Nicholas Tiller explains: “They are designed to give very confident, very authoritative responses, and that conveys a sense of credibility, so the user assumes that it must know what it’s talking about.” He thinks chatbots should be avoided for health advice unless you have the expertise to know when the AI is getting the answers wrong.

The study’s Conclusions The audited chatbots performed poorly when answering questions in misinformation-prone health and medical fields. Continued deployment without public education and oversight risks amplifying misinformation. Tiller NB, Marcon AR, Zenone M, et al

Generative artificial intelligence-driven chatbots and medical misinformation: an accuracy, referencing and readability audit BMJ Open 2026;16:e112695. doi: 10.1136/bmjopen-2025-112695 https://bmjopen.bmj.com/content/16/4/e112695

Wow.

Now go read this thread posted on LinkedIn https://www.linkedin.com/posts/gratuz_ai-llm-activity-7358862577512165376-Q7AA

Yikes.

America’s Largest Hospital System Ready to Start Replacing Radiologists With AI

“We could replace a great deal of radiologists with AI at this moment, if we are ready to do the regulatory challenge,”
Mitchell Katz, president and CEO of New York’s 11-hospital public benefit corporation

Mohammed Suhail, a radiologist at North Coast Imaging in San Diego, told Radiology that Katz’s comments are “undeniable proof that confidently uninformed hospital administrators are a danger to patients (and are) ..“easily duped by AI companies that are nowhere near capable of providing patient care.”

America’s Largest Hospital System Ready to Start Replacing Radiologists With AI, Its CEO Says – https://futurism.com/artificial-intelligence/hospital-ceo-ai-radiology

Confidently. Uninformed.

Yikes.

America’s Next Epidemic is Happening in Canada

Sports betting is being marketed to young Americans as an investment. Social media has perpetuated the idea that betting on sports is a profitable venture, leading to the normalization of unsafe and risky behavior. The legalization of prediction markets like Kalshi and Polymarket have only reinforced that messaging. America’s next epidemichttps://www.bettoroff.org/about-6-1

Nearly one in four (23.5%) young adults, aged 18 to 29, who reported gambling online in the past year experienced high levels of gambling-related harms, including financial, emotional, psychological and relationship harms. Online Gambling Among Young Canadian Adults: A Call to Actionhttps://www.ccsa.ca/en

Yikes.

GLP-1s (it’s kind of a mess)

“But the real question is what is the quality of the weight regain and what is the shift in people’s metabolism, and it seems to be very bad,” she said. “Ongoing studies that haven’t been published yet suggest that hypertension comes back. All the inflammatory markers come back, and lipids go up. And if you have diabetes, it gets worse. Overall, it’s kind of a mess…As these studies and others showed, most people regain the weight. Whether or not they regain all the weight depends in part on diabetes and insulin and many other factors, but people will likely regain most of their weight.”

“But the message isn’t that you regain the weight. The message is that you may be less healthy when you regain the weight. That’s why we need to couple the drugs with lifestyle interventions. And it’s why people who just want to lose 5 or 10 pounds really need to consider that lifestyle change, hard as it is, is the better way to do it.”

Anne Peters, MD, professor Keck School of Medicine of the University of Southern California

Less Weight Regain, More Health Loss after Stopping GLP-1s? – Medscape – March 05, 2026 – https://www.medscape.com/viewarticle/less-weight-regain-more-health-loss-after-stopping-glp-1s-2026a10006rv?

I never envisioned developing an obsession with pharmaceuticals. And after many years of endless blogging into the void I learned I could link to previous posts like this: https://lifeunderwriter.net/tag/glp-1-receptor-agonist/

The learning never stops.

GLP-1s and the Risk for Malnutrition

“We see cases where people take a GLP-1 medication and become so severely malnourished that they need to be hospitalized,” said Rebecca Boswell, PhD, director of Penn Medicine Princeton Center for Eating Disorders, in Philadelphia. “It’s not uncommon.” The Scary Health Risk That Can Sneak Up on GLP-1 Users – Medscape – January 19, 2026. https://www.medscape.com/viewarticle/scary-health-risk-can-sneak-glp-1-users-2026a10001pi

Yikes.

People return to their baseline weight and lose all cardiometabolic benefits in less than 2 years after stopping semaglutide or tirzepatide, a new meta-analysis found. Weight Regain, Health Benefit Loss Rapid When GLP-1s Stopped – Medscape – January 08, 2026. https://www.medscape.com/viewarticle/weight-regain-health-benefit-loss-rapid-when-glp-1s-stopped-2026a10000kr?

YIKES.

You see, cures are passée. Cures kill markets. Getting the population properly hooked on a pharmaceutical treatment for a ‘chronic’ condition is where the serious money is. “Our core insight was simple and grim: it’s far easier—and infinitely more profitable—to convince healthy people that they’re sick than to develop genuine cures for the truly ill.

Twenty years later, the hustle is bigger, slicker, and more dangerous than ever. Watching that hustle unfold with weight loss drugs feels weirdly ominous, like watching a slow-moving train wreck you can’t peel your eyes off of. You know there’ll be carnage and bodies, vast fortunes won and lost, and humanity left just a little bit poorer. We have often documented the pharmaceutical industry’s proven ability to create enormously lucrative markets overnight, by inventing and selling diseases. Now watch as all that ingenuity and energy gets pointed at one of the biggest problems bewitching humanity: human fatness. The Seven Deadly Sins of Weight Loss Drugshttps://brownstone.org/articles/the-seven-deadly-sins-of-weight-loss-drugs/

YIKES!

This will not end well.

Complications? What Complications? (just another GLP-1 receptor agonist post)