No fake apologies will be forthcoming if you are offended by this comedian.
Profits not People
New Wonder Drug! Treat Diabetes, Obesity AND Addiction – (yup another GLP-1 receptor agonist post)
Previous research has found that activating GLP-1 receptors in rats’ brain causes the animals to eat less of a high-sugar chow, which they would normally prefer over a less delicious but healthier bland meal when given the option. This suggests that GLP-1 makes unhealthy food less rewarding. Schmidt’s team found the same to be true with cocaine: rats that received a GLP-1 agonist took less cocaine when it was offered. The researchers are now repeating the experiments in rats addicted to opioids or fentanyl. Several other studies have shown that GLP-1 agonists cause rats to drink less alcohol and produce less dopamine when they do drink, suggesting that the activity is no longer as pleasurable.
…it’s too early to say whether people recovering from addiction would need to take an GLP-1 agonist for the rest of their lives, like people with diabetes do, or whether these drugs could be short-term treatments that curb cravings long enough for people to make lifestyle changes to stay sober. People who stop taking semaglutide for weight loss quickly gain the weight back, and study animals that stop taking it return to alcohol and drug use, but “I don’t think we know enough yet” in humans, Simmons says.
Could New Weight-Loss Drugs like Ozempic Treat Addiction? — https://www.scientificamerican.com/article/could-new-weight-loss-drugs-like-ozempic-treat-addiction1/
The rest of this post is a repost of April Fools 2023 (this is a GLP-1 receptor agonist post). Enjoy!
Ozempic and a similar drug, Wegovy, are weekly shots you give yourself that cause the body to produce insulin. Insulin lowers blood sugar, slows digestion and makes people feel full. Carter-Williams tried it and was amazed.
“You are not hungry,” she says. “Like, I actually have to set timers to make sure that I do eat, because otherwise you actually forget to eat.”
‘You forget to eat’: How Ozempic went from diabetes medicine to blockbuster diet drug https://www.npr.org/2023/04/01/1166781510/ozempic-weight-loss-drug-big-business
Everyone wants the easy way out. I sometimes forget to eat but not because of a miracle drug. You wonder if those of us wanting to lose weight know you can’t stop taking this drug once you start it.
Patients discontinuing the use of weight-loss drugs such as Wegovy risk regaining their original body weight in about five years, a Novo Nordisk official said on Wednesday.
Novo Nordisk Says Stopping Obesity Drug May Cause Full Weight Regain in 5 Years–https://www.medscape.com/viewarticle/990267?src=rss
Side effects?
Just a few https://www.wegovy.com/taking-wegovy/side-effects.html
- Possible thyroid tumors, including cancer.
- Inflammation of your pancreas (pancreatitis)
- Gallbladder problems
- Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin
- Kidney problems (kidney failure)
- Serious allergic reactions
- Change in vision in people with type 2 diabetes.
- Increased heart rate
- Depression or thoughts of suicide.
So if you want to lose weight by taking a GLP-1 receptor agonist remember the risks of side effects including the real possibility of having to take a drug that costs up to $1600.00 a month for the rest of your life.
Good luck with that.
As an FYI this drug class is being investigated by the EU for a small number of cases reporting suicidal ideation https://www.latimes.com/business/story/2023-07-10/ozempic-weight-loss-drugs-probed-over-reports-of-suicidal-thoughts.
But we already knew this.
Why People Stop Using Drugs Like Ozempic – Wired (yet another GLP-1 receptor agonist post)
One study looked at GLP-1 RAs prescribed in the UK between 2009 and 2017. Out of the 589 patients who started taking a GLP-RA, 45 percent stopped taking the drug within 12 months, and 65 percent within 24 months. The same group of scientists also looked at people taking GLP-1 RAs in the US across a similar period of time. That study included a much larger group of diabetes patients but found that people quit taking the drugs at a similar rate as in the UK. Within 12 months, 47 percent of patients stopped taking their GLP-1 AR; after 24 months that figure was 70 percent. On average, people in that study spent around 13 months using the drug before they stopped taking it.
Why People Stop Using Drugs Like Ozempic —https://www.wired.com/story/ozempic-wegovy-quitting-weight-loss/?utm_source=pocket-newtab
For my last GLP-1 RA post see Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes — https://doi.org/10.2337/dc22-1710
To reduce the number of clicks the rest of this post is a repost of April Fools 2023 (this is a GLP-1 receptor agonist post). Enjoy!
Ozempic and a similar drug, Wegovy, are weekly shots you give yourself that cause the body to produce insulin. Insulin lowers blood sugar, slows digestion and makes people feel full. Carter-Williams tried it and was amazed.
“You are not hungry,” she says. “Like, I actually have to set timers to make sure that I do eat, because otherwise you actually forget to eat.”
‘You forget to eat’: How Ozempic went from diabetes medicine to blockbuster diet drug https://www.npr.org/2023/04/01/1166781510/ozempic-weight-loss-drug-big-business
Everyone wants the easy way out. I sometimes forget to eat but not because of a miracle drug. You wonder if those of us wanting to lose weight know you can’t stop taking this drug once you start it.
Patients discontinuing the use of weight-loss drugs such as Wegovy risk regaining their original body weight in about five years, a Novo Nordisk official said on Wednesday.
Novo Nordisk Says Stopping Obesity Drug May Cause Full Weight Regain in 5 Years–https://www.medscape.com/viewarticle/990267?src=rss
Side effects?
Just a few https://www.wegovy.com/taking-wegovy/side-effects.html
- Possible thyroid tumors, including cancer.
- Inflammation of your pancreas (pancreatitis)
- Gallbladder problems
- Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin
- Kidney problems (kidney failure)
- Serious allergic reactions
- Change in vision in people with type 2 diabetes.
- Increased heart rate
- Depression or thoughts of suicide.
So if you want to lose weight by taking a GLP-1 receptor agonist remember the risks of side effects including the real possibility of having to take a drug that costs up to $1600.00 a month for the rest of your life.
Good luck with that. This joke’s on you.
As an FYI this drug class is being investigated by the EU for a small number of cases reporting suicidal ideation https://www.latimes.com/business/story/2023-07-10/ozempic-weight-loss-drugs-probed-over-reports-of-suicidal-thoughts.
But we already knew this.
Is There a Difference?
Same graphic, slightly larger.
Never present yourself than anything other than your true self.
Oklahoma producing 64 times more marijuana than licensed users consume – The Oklahoman
“The supply-to-demand ratio of regulated medical marijuana supply to regulated medical cannabis demand is 64:1,” the report states. “Using a general assumption that units of supply should not exceed two times the units of demand, the medical marijuana program has no less than 32 times more regulated marijuana necessary than licensed patient demand.”
The significant oversupply is likely funneling large amounts of marijuana out of state and adding to the illegal market, according to authority officials.
Oklahoma producing 64 times more marijuana than licensed users consume, report shows — https://www.oklahoman.com/story/news/state/2023/06/21/marijuana-oklahoma-overproducing-64-times-omma-report/70343452007/
The Truth behind the medical marijuana industry.
At least we know there may be a positive longevity effect to all of this excess supply.
Scary Charts (Beyond BMI) – 06.04.23
The value of the BMI for tracking the current epidemic of obesity is clearly illustrated in the study by Rodgers et al., which traced the change in the BMI for many subgroups of the US population from 1962 to the year 2000 [23]. (See Figure 1) They showed that the US epidemic of obesity began about 1975 in all age, sex and ethnic groups and continued over the next 25 years. This fact limits the plausible explanations for the current epidemic of obesity. Rodgers and colleagues believe that it is implausible that each age, sex and ethnic group, with massive differences in life experience and attitudes, had a simultaneous decline in willpower related to healthy nutrition or exercise, or that intrauterine exposures played a major causative role. Likewise, changes in genetic make-up are unlikely to have occurred over this short period and to have affected all age groups simultaneously. Similarly, they note that it is unlikely that any factor with a long induction period had a major role in the US epidemic. Rather, they believe that the epidemic must have been caused by factors that led to rapid population-wide changes such as changes in the food supply, and I tend to agree with their conclusion.
Beyond BMI by George A. Bray – Nutrients 2023, 15(10), 2254 – https://doi.org/10.3390/nu15102254
Agree.
Scary Charts – 06.01.23
Source article here https://www.statista.com/chart/19537/single-family-home-prices-in-the-us-by-price-category/
And also from Statista:
We are doomed.
Elder Abuse
Most of the time I just delete shit like this. Then, unsurprisingly I get another text.
What chat? Why do I feel like I’m being targeted?
HomeVestors, the self-proclaimed “largest homebuyer in the United States,” goes to great lengths to distinguish itself from the hedge funds and YouTube gurus that have taken over large swaths of the real estate investment market. The company says it helps homeowners out of jams — ugly houses and ugly situations — improving lives and communities by taking on properties no one else would buy. Part of that mission is a promise not to take advantage of anyone who doesn’t understand the true value of their home, even as franchisees pursue rock-bottom prices…HomeVestors cautions its franchisees never to take advantage of sellers who are unable to understand negotiations. But by the time he left that evening, Evans had a contract to buy the house for roughly two-thirds its value, signed in Casanova’s shaky script.
The Ugly Truth Behind “We Buy Ugly Houses” — https://www.propublica.org/article/ugly-truth-behind-we-buy-ugly-houses
Full disclosure – I have no clue who sent me these text messages and the source may not be HomeVestors.
Please read then share the entire article. You can’t be too safe nowadays.
The more I think about this form of elder abuse the angrier I get. Then again, maybe I did have a conversation about a different property.
This text message was for a property I don’t own.
SARMs (Selective Androgen Receptor Modulators)
SARMs, which are chemical substances that mimic the effects of testosterone and anabolic steroids, are not FDA approved. Online vendors and social media influencers are using social media to make SARMs seem safe and effective.
The reality is SARMs are potentially dangerous. The FDA continues to receive adverse event reports associated with SARMS use. The real number of consumers experiencing adverse events is likely higher due to underreporting. Because these are not approved drugs, consumers may be reluctant to report adverse events or may not be aware that they can report adverse events that they experience. In addition, they might not know that their symptoms are being caused by the product.
Studies and reports show SARMs are associated with serious or life-threatening health problems, such as:
FDA Warns of Use of Selective Androgen Receptor Modulators (SARMs) Among Teens, Young Adults — https://www.fda.gov/consumers/consumer-updates/fda-warns-use-selective-androgen-receptor-modulators-sarms-among-teens-young-adults
- Increased risk of heart attack or stroke
- Psychosis/hallucinations
- Sleep disturbances
- Sexual dysfunction
- Liver injury and acute liver failure
- Infertility
- Pregnancy miscarriage
- Testicular shrinkage
If you’ve read this far, congratulations. Now spread the word.
Tirzepatide (another GLP-1 receptor agonist post)
Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes — https://doi.org/10.2337/dc22-1710
To reduce the number of clicks the rest of this post is a repost of April Fools 2023 (this is a GLP-1 receptor agonist post). Enjoy!
Ozempic and a similar drug, Wegovy, are weekly shots you give yourself that cause the body to produce insulin. Insulin lowers blood sugar, slows digestion and makes people feel full. Carter-Williams tried it and was amazed.
“You are not hungry,” she says. “Like, I actually have to set timers to make sure that I do eat, because otherwise you actually forget to eat.”
‘You forget to eat’: How Ozempic went from diabetes medicine to blockbuster diet drug https://www.npr.org/2023/04/01/1166781510/ozempic-weight-loss-drug-big-business
Everyone wants the easy way out. I sometimes forget to eat but not because of a miracle drug. You wonder if those of us wanting to lose weight know you can’t stop taking this drug once you start it.
Patients discontinuing the use of weight-loss drugs such as Wegovy risk regaining their original body weight in about five years, a Novo Nordisk official said on Wednesday.
Novo Nordisk Says Stopping Obesity Drug May Cause Full Weight Regain in 5 Years–https://www.medscape.com/viewarticle/990267?src=rss
Side effects?
Just a few https://www.wegovy.com/taking-wegovy/side-effects.html
- Possible thyroid tumors, including cancer.
- Inflammation of your pancreas (pancreatitis)
- Gallbladder problems
- Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin
- Kidney problems (kidney failure)
- Serious allergic reactions
- Change in vision in people with type 2 diabetes.
- Increased heart rate
- Depression or thoughts of suicide.
So if you want to lose weight by taking a GLP-1 receptor agonist remember the risks of side effects including the real possibility of having to take a drug that costs up to $1600.00 a month for the rest of your life.
Good luck with that. This joke’s on you.
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