Loneliness and Mortality

The discomfort of loneliness eases with time. You come to accept solitude like a cracked tile in a corner of the bathroom floor. Eventually, you just stop noticing the defect. For older people, however, one crack could easily, quietly, lead to more. Living in isolation, for people over 50, can spur a 50 percent increased risk of dementia, according to the CDC, and a 32 percent increased risk of stroke. Loneliness is also associated with higher rates of anxiety, depression, and suicide. Prolonged isolation is the equivalent to smoking 15 cigarettes a day. (And older members of marginalized communities are at an even higher risk for all of the above when they’re socially secluded.) In the years since my mom lost her husband and her friends in Florida, her health declined and her shine dimmed. The woman who owns more makeup than Dolly Parton — including Stila compacts from the early aughts she audaciously calls “my vintage cosmetics” — stopped putting on her face.

My Mom Has No Friends — https://www.thecut.com/2022/08/helping-my-mom-make-friends.html

A beautifully written article. I hope you choose to read the entire piece.

Covid-19: is omicron less lethal than delta?

This study provides the most conclusive evidence to date that infection with the omicron subvariant BA.1 was inherently less deadly than delta when controlling for a number of key covariates. Combining death certification records with molecular surveillance is the main advantage of this study, which avoids previous biases in covid-19 death designations. Accounting for a broad array of standardised covariates, including sociodemographic variables, pre-existing health conditions, and previous immunity, is another strength.

BMJ 2022; 378 doi: https://doi.org/10.1136/bmj.o1806 (Published 02 August 2022)

Quote from the BMJ editorial. Here’s the link to the study:

Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta (B.1.617.2): retrospective cohort study — BMJ 2022; 378 doi: https://doi.org/10.1136/bmj-2022-070695

A Plan is Not a Strategy – Update 08.03.22

A few months ago I was thinking about retirement. The funny thing about life at “retirement age” and still working is you think about retirement a lot. See Thinking About Retirement (or just another fine Saturday Morning) While catching up on news I came across several articles on unretirement. I learned the word unretire is actually in the dictionary. See https://www.merriam-webster.com/dictionary/unretire. Rather than retire then unretire I decided I needed a plan. The more I thought about coming up with a plan the more I realized I needed a strategy instead.

So now I’m working on strategy only to realize I’ve had a strategy for many years. I’ve just never taken the time to write it down. It might be time to document my strategy. But it’s been too hot to write and Too Hot to Blog.

Take Home Message: A Plan is Not a Strategy.

Update 08.03.22

For an excellent example of strategy read this piece https://www.noceilingsnba.com/p/the-art-of-presti on how Sam Presti the General Manager of the OKC Thunder epitomizes this definition of strategy.

SIDD, SIRD, MOD, AND MARD – DM2 Subgroups

Type 2 diabetes (T2D) was recently reclassified into severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD), which have different risk of complications. We explored whether DNA methylation differs between these subgroups and whether subgroup-unique methylation risk scores (MRSs) predict diabetic complications.

Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns That Associate With Future Diabetic Complications — https://doi.org/10.2337/dc21-2489

More acronyms!

Don’t Let Your Cat Sneeze on You

Researchers say the results are convincing. They are surprised that it has taken this long to establish that transmission can occur, given the scale of the pandemic, the virus’s ability to jump between animal species, and the close contact between cats and people. “We’ve known this was a possibility for two years,” says Angela Bosco-Lauth, an infectious-disease researcher at Colorado State University in Fort Collins.

First reported case of a person getting COVID from a cat — https://www.nature.com/articles/d41586-022-01792-y
Photo by Kirsten Bu00fchne on Pexels.com

Deer too. https://www.nature.com/articles/d41586-022-01112-4

Photo by Pixabay on Pexels.com

Don’t forget about hamsters. https://www.nature.com/articles/d41586-022-00322-0

Photo by Faris Subriun on Pexels.com

Or mink mutations…

Fonager says researchers in Denmark have sequenced viral samples from 40 mink farms and identified some 170 coronavirus variants. He adds that in viral samples from people — representing about one-fifth of the country’s total COVID confirmed cases — they’ve found some 300 people with variants that contain mutations thought to have first emerged in mink. “That is something we really want to keep a close eye on.”

COVID mink analysis shows mutations are not dangerous — yet — https://www.nature.com/articles/d41586-020-03218-z

Protein Blobs!

The African turquoise killifish lives in transitory ponds in East Africa that form during the rainy season. As the fish nears the end of its 4- to 6-month life, it develops a range of age-related diseases, including cataracts and brain-related changes that resemble neurodegenerative disorders like Alzheimer’s in humans. Its brief life span — much shorter than that of a lab mouse, for example — and rapid natural aging make it an ideal model for studying aging in vertebrates. The Stanford team conducted an extensive analysis of the proteins in killifish at various stages of youth and maturity. In the aging killifish, they discovered protein aggregates in all the tissues that they looked at: not only the brain but also the heart, gut, liver, muscle, skin and testis. More than half of the aggregating proteins seemed to show an intrinsic tendency to aggregate in further experiments.

Protein Blobs Linked to Alzheimer’s Affect Aging in All Cells — https://www.quantamagazine.org/protein-blobs-linked-to-alzheimers-affect-aging-in-all-cells-20220628
Photo Credit: MDI Biological Laboratory; Itamar Harel

Fascinating article. And regarding the video clip, sorry I couldn’t resist.