Vitamin D Dosing: Too Low to Matter?

Autier and colleagues found that vitamin D deficiency, in the observational studies, was associated with cardiovascular diseases, inflammation, glucose metabolism disorders, infectious diseases, mood disorders, declines in cognitive function, and even all-cause mortality.

With the exception of colorectal cancer, being vitamin D sufficient did not appear to reduce the risk of developing various types of cancer.

Vitamin D sufficiency was associated with a lower risk of cardiovascular events (up to 58%), diabetes (up to 38%), colorectal cancer (up to 33%), and all-cause mortality (29%).

via Vitamin D Dosing: Too Low to Matter?.

HbA1c and the Risks for All-Cause and Cardiovascular Mortality in the General Japanese Population

High HbA1c levels were associated with increased risk for all-cause mortality and death from CVD, coronary heart disease, and cerebral infarction in general East Asian populations, as in Western populations.

via HbA1c and the Risks for All-Cause and Cardiovascular Mortality in the General Japanese Population.

Testosterone Treatment Tied to Worse Cardiac Outcomes

After adjustment for the presence of coronary artery disease, testosterone therapy was associated with a greater risk of all-cause mortality, myocardial infarction, and ischemic stroke 3 years after angiography (25.7% versus 19.9%; HR 1.29, 95% CI 1.04-1.58), according to P. Michael Ho, MD, PhD, of the Department of Veterans Affairs (VA) Eastern Colorado Health Care System in Denver, and colleagues.

via Testosterone Tx Tied to Worse Cardiac Outcomes.

How come the television commercials don’t tell you this information when they try to make you think you have a disease called Low T?

Annual prescriptions for testosterone increased more than five-fold from 2000 to 2011. In 2011, the total number of prescriptions numbered 5.3 million and make up a market of 1.6 billion, the authors wrote.

Never mind.

Life Stressors Increase Mortality Risk

When they looked at life stressors and mortality, they found that 510 persons said they experienced none of the 10 major life events, and over the course of the follow-up, 159 of them died. Of the 853 people who listed one major life event, 276 died — a crude nonsignificant 4% increased risk of all-cause mortality compared with those having no life stressors.

Of the 588 individuals who experienced two life stressors, 213 died, translating to a crude 21% increased risk that also failed to achieve statistical significance. The researchers identified 257 people who experienced three life stressors, and 101 of them died, a crude 50% increase in all-cause mortality that was significant. They also reported that 177 persons experienced four or more life events, and 78 of that group died, translating to a crude all-cause mortality increase was 60% higher than those with no life stressors, also significant.

When the researchers adjusted for age and sex, the significant findings held for those with three or more events. When the figures were also adjusted for glycemic parameters, type 2 diabetes prevalence, body mass index, hypertension and cardiovascular disease prevalence, significance remained for those with four or more life stressor events — a 38% increased risk (95% CI 1.0-1.8), Rutters said.

via Life Stressors Increase Mortality Risk.

How do I live longer? (get a plant)

In a study of nursing home patients by researchers Ellen Langer and Judith Rodin, residents on one floor were given a plant for which they themselves were expected to care (the experimental group) while residents on another floor were given a plant for which their nurses would care (the control group). After three weeks, 93 percent of residents in the experimental group showed an overall improvement in socialization, alertness, and general function; in contrast, for 71 percent of residents in the control group functioning actually declined. And in a follow-up study eighteen months later, half as many of the residents who’d received plants for which they were expected to care by themselves had died as the residents who’d been given plants for which their nurses cared.

via How do I live longer? Here are 10 ways backed by evidence.

Great post.  To sum up: exercise, be happy, be optimistic, tell yourself aging is a good thing, and get a plant.

Association of Clinical Symptomatic Hypoglycemia With Cardiovascular Events and Total Mortality in Type 2 Diabetes

CONCLUSIONS: Symptomatic hypoglycemia, whether clinically mild or severe, is associated with an increased risk of cardiovascular events, all-cause hospitalization, and all-cause mortality. More attention may be needed for diabetic patients with hypoglycemic episodes.

via Association of Clinical Symptomatic Hypoglycemia With Cardiovascular Events and Total Mortality in Type 2 Diabetes.

Watch those hypoglycemic episodes in applicants with T2DM.