NT-proBNP is a strong independent predictor of short-term CV mortality risk in elderly people with type 2 diabetes, including those without preexisting CVD. This association is evident even in people with slightly increased values, is not modified by CRP, and is additive to that provided by AER.
NT proBNP
Biomarkers May Help Heart Failure Risk Prediction
After accounting for the clinical risk score, several echocardiographic findings were independently associated with incident heart failure HRs 1.11 to 2.91, P≤0.001 for all:
- Reduced left ventricular ejection fraction
- Abnormal mitral inflow E/A peak velocity ratio a measure of diastolic function
- Enlarged left atrium Increased left ventricular mass
These variables were used to create an echocardiographic score.Elevated levels of NT-proBNP also were independently associated with heart failure risk HR 1.61 as a continuous variable and HR 2.7 for values greater than 190 pg/mL, P
NT-proBNP Not Predictive in Healthy Normal People
Conclusions: The investigators concluded that these findings do not support the use of NT-proBNP as a cardiovascular biomarker in healthy normal subjects, and have important implications for NT-proBNP–based strategies for early detection and primary prevention of cardiovascular disease.
Biomarkers in NSTE-ACS
Prognostic Value of Biomarkers During and After Non–ST-Segment Elevation Acute Coronary Syndrome
Even during follow-up, NT-proBNP demonstrated the strongest association to the composite endpoint of death/myocardial infarction.
If I find a good article/tutorial on NT-proBNP I’ll post it.
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