Moderate-to-severe OSA was associated with a 2.5-fold higher likelihood of incident cancer (95% CI 1.2-5.0) after adjustment for obesity and a full range of other factors, Nathaniel Marshall, PhD, of the University of Sydney Nursing School in Australia, and colleagues found.
Cancer mortality was 3.4 times more common (95% CI 1.1-10.2) in those with sleep apnea than with no sleep apnea during 20 years of follow-up, they reported in the April 15 issue of theJournal of Clinical Sleep Medicine.
OSA
Obstructive Sleep Apnea and Diabetic Nephropathy
OSA is independently associated with DN in type 2 diabetes. eGFR declined faster in patients with OSA. Nitrosative stress may provide a pathogenetic link between OSA and DN. Interventional studies assessing the impact of OSA treatment on DN are needed.
Sleep Apnea Plays Role in Car Crashes
An estimated 20% to 50% of commercial drivers have sleep apnea. That high proportion may be in part due to the sedentary nature of long-haul trucking that contributes to obesity as a risk factor for sleep apnea, according to a statement from the American Academy of Sleep Medicine in support of federal legislation.
via Sleep Apnea Plays Role in Car Crashes.
Presented without the usual caustic comment.
Sleep Apnea Severity Tied to Cardiac Marker
- Obstructive sleep apnea is associated with cardiovascular morbidity and mortality, particularly heart failure, a study found.
- The severity of obstructive sleep apnea was significantly associated with higher levels of high-sensitivity troponin, suggesting that subclinical myocardial injury may play a role in the association with risk of heart failure.
Apnea: ‘Sleeping Gun’ in Sudden Death?
After adjustment for other risk factors, each 10% decrease in the lowest nocturnal oxygen saturation among adults undergoing a first-time polysomnogram for suspected sleep-disordered breathing was associated with a 14% greater risk of sudden cardiac death or resuscitated cardiac arrest (HR 1.14, 95% CI 1.01 to 1.27), according to Virend Somers, MD, PhD, of the Mayo Clinic in Rochester, Minn., and colleagues.
Sleep factors associated with a significantly greater likelihood of remaining free from sudden cardiac death or resuscitated cardiac arrest included an apnea-hypopnea index of less than 20 events per hour (HR 1.60, 95% CI 1.14-2.24), a mean nocturnal oxygen saturation of 93% or higher (HR 2.93, 95% CI 1.98-4.33), and a lowest nocturnal oxygen saturation of 78% or higher (HR 1.81, 95% CI 1.28-2.56), the researchers reported online in the Journal of the American College of Cardiology.
via Apnea: ‘Sleeping Gun’ in Sudden Death
Yes. CPAP compliance matters.
Artery Damage Seen in Sleep Apnea
People with obstructive sleep apnea (OSA) have subclinical arterial disease on par with that seen in patients with diabetes, researchers found.
Patients with moderate to severe obstructive sleep apnea have endothelial dysfunction and arterial stiffness, similar to patients with diabetes mellitus.
via Artery Damage Seen in Sleep Apnea.
Small study with some interesting findings.
Bad Sleep Tied to Cognitive Decline
Medical News: Bad Sleep Tied to Cognitive Decline – in Meeting Coverage, AAIC from MedPage Today.
Sleeping too little or too much, abnormal breathing during sleep, and excessive daytime sleepiness all were significantly associated with cognitive impairment — years later in some cases.
Neurocognitive Impairment in Obstructive Sleep Apnea
Declining Kidney Function Increases Prevalence of Sleep Apnea
Conclusions: Sleep apnea is common in patients with CKD and increases as kidney function declines. Almost 50% of patients with CKD and ESRD experience nocturnal hypoxia, which may contribute to loss of kidney function and increased cardiovascular risk.
via Declining Kidney Function Increases the Prevalence of Sleep Apnea and Nocturnal Hypoxia.
Prevalence of Diagnosed Sleep Apnea Among Patients With Type 2 Diabetes in Primary Care
Prevalence of Diagnosed Sleep Apnea Among Patients With Type 2 Diabetes in Primary Care.
Conclusions: Primary care providers under diagnose OSA in patients with T2DM.
Up to 90% of patients with type 2 diabetes mellitus (T2DM) have obstructive sleep apnea (OSA).
Think about that.
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