Doctors should be cautious about prescribing statin drugs for primary prevention in people at low risk of cardiovascular events — because of shortcomings in the evidence to support such use, a Cochrane review warned.
pharmaceutical
Vorapaxar Phase III Update
Whoops.
The novel antithrombotic vorapaxar causes intracranial hemorrhage in patients with a history of stroke, Merck announced, explaining why stroke survivors were dropped from trials of the experimental drug.

Vilazodone (Viibryd) = New Antidepressant
Medical News: FDA Approves New Antidepressant – in Product Alert, Prescriptions from MedPage Today
Vilazodone (Viibryd) has been approved for treatment of major depression, the FDA announced.
Bye Bye Darvon
Duloxetine Hydrochloride (Cymbalta) – It’s Not Just for Depression Anymore
If Your Leg Breaks Stop Taking Biphosphonates
The highlighted bold is me. I keep reading this FDA recommendation just to make sure I understand what they are trying to say. I think the recommendation says the FDA found no cause and effect between the use of biphosphonates and leg fractures so keep taking your medication. But if your leg breaks, your physician will instruct you to stop taking the medication she prescribed for you to help prevent bone loss and fractures.
I’m glad the FDA cleared up this issue, don’t you?
BACKGROUND: Atypical subtrochanteric femur fractures are fractures in the bone just below the hip joint. Diaphyseal femur fractures occur in the long part of the thigh bone. These fractures are very uncommon and appear to account for less than 1% of all hip and femur fractures overall. Although it is not clear if bisphosphonates are the cause, these unusual femur fractures have been predominantly reported in patients taking bisphosphonates.
RECOMMENDATIONS: Patients should continue to take their medication unless told to stop by their healthcare professional. FDA recommends that healthcare professionals should discontinue potent antiresorptive medications (including bisphosphonates) in patients who have evidence of a femoral shaft fracture. See the FDA Drug Safety Communication below for additional information.

Thinking Differently About Medications in the Elderly
Kapvay (clonidine hydrochloride)
Underwriting Quick Notes
Kapvay = brand name
Shionogi = manufacturer
Tygacil (tigecycline) – Increased Mortality Risk
This will cure the infection…permanently.
Liver Enzymes and Statins
I stumbled across this article while evaluating a persistent CPK elevation in an applicant with HLD and other CHD risk factors.
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