Benzodiazepines Implicated in High Rate of ED Visits Across US

Seven out of eight emergency department (ED) visits attributed to adverse events from benzodiazepines involve self-harm or nonmedical use of these drugs, and more than 80% involve concurrent use of alcohol, illicit drugs, or other substances, new research shows.

Although benzodiazepines are typically not problematic in terms of acute overdoses when used alone, patients often don’t take them as prescribed or use them with other substances in a self-harm attempt, author Daniel S. Budnitz, MD, MPH, director of the Medication Safety Program, Centers for Disease Control and Prevention (CDC), told Medscape Medical News.

“Clinicians need to be aware of what other substances patients might be taking when they’re being prescribed a benzodiazepine,” Budnitz added.

The study was published online February 19 in the American Journal of Preventive Medicine.

Benzodiazepines Implicated in High Rate of ED Visits Across US – Medscape – Feb 25, 2020 – https://www.medscape.com/viewarticle/925686#vp_1

Updated benzodiazepine boxed warning: What you need to know

“I took the medication only as prescribed,” Bobbi said. After her benzodiazepine was stopped abruptly, she suffered multiple disabling neurological symptoms, including seizures, cognitive and visual impairment, difficulty walking, and hand contractures, leaving her unable to work. Bobbi is one of many patients my advocacy organization helped report their harm to the FDA. Our goal was to raise awareness of the adverse effects of benzodiazepines and advocate for stronger warning labels.

Thus, I was pleasantly surprised last September to see the FDA’s drug safety communication announcing an update to the boxed warning for benzodiazepines “to address the serious risks of abuse, addiction, physical dependence, and withdrawal reactions.” Curious, I filed a FOIA request for the FDA’s 175-page report on benzodiazepines. Many of the document’s conclusions raise the same concerns benzodiazepine safety advocates have had for decades.

updated benzodiazepine boxed warning: What you need to know — https://www.kevinmd.com/blog/2021/03/the-updated-benzodiazepine-boxed-warning-what-you-need-to-know.html

I downloaded the FDA report for future reference.

The report should be fun weekend reading.

SARS-CoV-2 mRNA vaccines induce a robust germinal centre reaction in humans

That lump in your armpit may actually be a good thing. The study is a pre-print with a small number of study subjects.

Meanwhile More Israeli Data

Vaccines shift the age distribution of the critically ill from SARS-CoV-2 to younger ages in the preliminary data from Israel. This is no time to let your guard down. Stay safe and get vaccinated as soon as you can.

Meanwhile in Israel…

In Israel, people who are 60 years and older were prioritized to get the vaccine first. When we analyze that group, we see that since the peak in mid-January, there’s now a 55% reduction in cases, 40% reduction in hospitalizations, 35% reduction in critically ill patients, and also now even a 35% reduction in mortality in that age group.

‘The Impact of the Vaccine Has Been Tremendous’ Medscape – Feb 17, 2021. — https://www.medscape.com/viewarticle/945680#vp_2