Shorter Life Expectancy Persists in Type 1 Diabetes

Colhoun said there have been few large-scale evaluations of life expectancy in type 1 diabetes, with the largest from the 1970s. To attain more current estimates, the researchers looked at data on 24,971 patients from Scotland with the disease — a cohort in which there were 1,079 deaths.

They then compared that information with data from the general population of Scotland with 12,055,160 people and 162,066 deaths.

Overall, they found significant gaps in life expectancy between type 1 diabetics and the general population — a difference of 11.1 years for men and 14.3 years for women between the ages of 20 and 25.

via Shorter Life Expectancy Persists in Type 1 Diabetes.

Life Stressors Increase Mortality Risk

When they looked at life stressors and mortality, they found that 510 persons said they experienced none of the 10 major life events, and over the course of the follow-up, 159 of them died. Of the 853 people who listed one major life event, 276 died — a crude nonsignificant 4% increased risk of all-cause mortality compared with those having no life stressors.

Of the 588 individuals who experienced two life stressors, 213 died, translating to a crude 21% increased risk that also failed to achieve statistical significance. The researchers identified 257 people who experienced three life stressors, and 101 of them died, a crude 50% increase in all-cause mortality that was significant. They also reported that 177 persons experienced four or more life events, and 78 of that group died, translating to a crude all-cause mortality increase was 60% higher than those with no life stressors, also significant.

When the researchers adjusted for age and sex, the significant findings held for those with three or more events. When the figures were also adjusted for glycemic parameters, type 2 diabetes prevalence, body mass index, hypertension and cardiovascular disease prevalence, significance remained for those with four or more life stressor events — a 38% increased risk (95% CI 1.0-1.8), Rutters said.

via Life Stressors Increase Mortality Risk.

Cows Vs Great Whites: Which Are More Likely to Kill You? – Physician’s Weekly

You rarely hear about a cow killing a human, but it happens about 20 times every year. Between 2003 and 2008, 108 people in the United States died from injuries caused by cattle, according to the Centers for Disease Control and Prevention. That’s 27 times the whopping 4 people killed in shark attacks in the United States during the same time period, according to the International Shark Attack File.

via Cows Vs Great Whites: Which Are More Likely to Kill You? | Physician’s Weekly.

Metformin and Cognitive Impairment

In a retrospective study, diabetic patients who were taking metformin had worse cognitive performance than those not taking the drug (odds ratio 2.23, 95% CI 1.05-4.75), Eileen Moore, PhD, of the University of Melbourne in Australia, and colleagues reported online in Diabetes Care.

Additionally, patients with diabetes who had vitamin B12 levels less than 250 pmol/L also had worse cognitive performance (OR 2.29, 95% CI 1.12-4.66), and the association between metformin and cognitive impairment was weakened after adjusting for vitamin B12 levels, they stated.

via In Some Patients Metformin Impairs Thinking.

What Profession Has The Highest Suicide Rate?

Physicians have the highest suicide rate of any profession.

via What I’ve learned from saving physicians from suicide.

Update 09.19.14

Suicide and the Young Physician – The Atlantic.

One might expect that older physicians, after years in an emotionally and often physically taxing profession, bear the burden of an increased suicide risk. But it is really a phenomenon of young physicians. Suicide accounts for 26 percent of deaths among physicians aged 25 to 39, as compared to 11 percent of deaths in the same age group in the general population.

N-Terminal Probrain Natriuretic Peptide Is a Stronger Predictor of Cardiovascular Mortality Than C-Reactive Protein and Albumin Excretion Rate in Elderly Patients With Type 2 Diabetes

NT-proBNP is a strong independent predictor of short-term CV mortality risk in elderly people with type 2 diabetes, including those without preexisting CVD. This association is evident even in people with slightly increased values, is not modified by CRP, and is additive to that provided by AER.

via N-Terminal Probrain Natriuretic Peptide Is a Stronger Predictor of Cardiovascular Mortality Than C-Reactive Protein and Albumin Excretion Rate in Elderly Patients With Type 2 Diabetes.

Cardiovascular Biomarkers, Cardiac Dysfunction, and Outcomes in Patients With Type 2 Diabetes: A Prospective, Multicenter Study

We report a lack of association between echocardiographic variables and laboratory biomarkers in a large population of type 2 diabetes patients without overt cardiac disease and mild alterations in LV function. The only laboratory marker found to predict 2-year outcomes in these patients was HbA1c. Neither the other laboratory markers (NT-proBNP, hsCRP, and UACR) nor echocardiographic markers provided independent prognostic information. The role of HbA1c as a guide for the appropriateness of treatment of patients with type 2 diabetes is supported by these findings.

via Cardiovascular Biomarkers, Cardiac Dysfunction, and Outcomes in Patients With Type 2 Diabetes: A Prospective, Multicenter Study.