Travel Advisory for Oklahoma – Updated 07.20.21(this is personal and not the US State Department)

The Delta VOC has arrived big time and I might be returning to crowd avoidance and curbside everything soon.

Northeast Oklahoma is likely the “tip of the spear” as the delta variant has taken hold in the state, Dr. Justin Mitchell of Integris Miami Hospital said last week. There, COVID-19 beds are full again — there are even more patients now than there were in January and February, when the pandemic was at its height in Oklahoma.

Oklahoma is facing another COVID-19 surge — https://www.oklahoman.com/story/news/2021/07/19/oklahoma-faces-another-covid-surge-leaving-unvaccinated-risk/8017015002/?utm_source=oklahoman-Daily%20Briefing&utm_medium=email&utm_campaign=daily_briefing&utm_term=hero&utm_content=OKLAHOMA-OKLAHOMACITY-NLETTER65

Viral infection and transmission in a large well-traced outbreak caused by the Delta SARS-CoV-2 variant

Viral infection and transmission in a large well-traced outbreak caused by the Delta SARS-CoV-2 variant

https://virological.org/t/viral-infection-and-transmission-in-a-large-well-traced-outbreak-caused-by-the-delta-sars-cov-2-variant/724

The link above will take you to the research study. If you go to Dr. Rasmussen’s Twitter thread you’ll find her insightful commentary on the study. In plain English.

Travel Advisory for Oklahoma (this is not the US State Department)

The Delta VOC has arrived and I might be returning to crowd avoidance and curbside pickup sooner than expected.

Travel Advisory for Mississippi (this is not the US State Department) – Updated

Dr. Dobbs has tweeted an update and correction.

Covid-19 and Young Adults – You Are Not Invincible (a gentle reminder)

Whistler recorded 1,120 COVID-19 cases from the beginning of January to March 28, with 218 of them last week alone, driven by the P.1 variant most commonly associated with Brazil. The majority of cases – 83.2 per cent – are in people aged 20 to 39.

Variant that forced B.C. ski resort shut is rapidly spreading, sending more young people to hospital — https://www.theglobeandmail.com/canada/article-covid-19-variant-spreading-rapidly-in-bc/

Young adults age 18 to 34 years hospitalized with COVID-19 experienced substantial rates of adverse outcomes: 21% required intensive care, 10% required mechanical ventilation, and 2.7% died. This in-hospital mortality rate is lower than that reported for older adults with COVID-19, but approximately double that of young adults with acute myocardial infarction.4 Morbid obesity, hypertension, and diabetes were common and associated with greater risks of adverse events. Young adults with more than 1 of these conditions faced risks comparable with those observed in middle-aged adults without them. More than half of these patients requiring hospitalization were Black or Hispanic, consistent with prior findings of disproportionate illness severity in these demographic groups.5,6

Clinical Outcomes in Young US Adults Hospitalized With COVID-19 — https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2770542

Please get vaccinated as soon as you’re eligible. This is a gentle reminder before I start getting a bit harsher with my messaging.

SARS-CoV-2 Variants – (in mice)

Pre-print therefore not peer reviewed. No, I don’t hang out on Twitter all day long. Yes, the study is somewhat geeky. BUT here’s the money sentence:

This abrogation of the species barrier raises the possibility of wild rodent secondary reservoirs and provides new experimental models to study disease pathophysiology and countermeasures.

The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice — https://www.biorxiv.org/content/10.1101/2021.03.18.436013v1

Now I can’t stop thinking about “secondary reservoirs”.