Kidney Disease and Increased Mortality Risk in Type 2 Diabetes

Among individuals with both diabetes and kidney disease, standardized mortality was 31.1% (95% CI, 24.7%–37.5%), representing an absolute risk difference with the reference group of 23.4% (95% CI, 17.0%–29.9%), adjusted for demographics, and 23.4% (95% CI, 17.2%–29.6%) when further adjusted. We observed similar patterns for cardiovascular and noncardiovascular mortality. In conclusion, those with kidney disease predominantly account for the increased mortality observed in type 2 diabetes.

via Kidney Disease and Increased Mortality Risk in Type 2 Diabetes.

Synthetic Marijuana Causes Kidney Failure in 15-year-old Oklahoma Teen

A Mustang High School student is recovering from kidney failure after smoking synthetic marijuana. He is one of two patients in an Oklahoma City hospital with kidney failure because of synthetic marijuana.

via Synthetic marijuana causes kidney failure in 15-year-old Oklahoma teen | NewsOK.com.

Change in Kidney Markers Not Just Function of Age

In a large cohort study, relative mortality risk for reduced eGFR was higher in every age category, but fell with increasing age (P<0.05), with similar albeit less evident findings for increased albuminuria, Josef Coresh, MD, PhD, of the Chronic Kidney Disease Prognosis Consortium Data Coordinating Center in Baltimore, and colleagues reported online in the Journal of the American Medical Association.

Overall, Coresh and colleagues found that death and ESRD risks were higher at lower eGFR and higher albuminuria in every age category.

via Change in Kidney Markers Not Just Function of Age.

Kidney Disease = Possible Risk for MI

In a large cohort study, patients with only CKD had a significantly higher rate of myocardial infarction (MI) than those who only had diabetes (5.4 versus 6.9 per 1,000 person-years, P

Those who’d already had an MI had the highest overall rate of MI (18.5 per 1,000 person-years), they reported online in The Lancet.

via Medical News: Kidney Disease May Point to Risk for MI – in Cardiovascular, Myocardial Infarction from MedPage Today.

Mortality Risk Quantified for Diabetes Plus Kidney Disease

This meta-analysis found that the presence of chronic kidney disease strongly predicted mortality risk in patients with type 2 diabetes. Chronic kidney disease more than doubles mortality risk in patients with type 2 diabetes, researchers found. In an analysis of nearly two dozen randomized controlled trials involving diabetic patients, the highest mortality rates were observed in those trials that required the inclusion of patients with renal disease, according to Marc Pfeffer, MD, PhD, of Brigham and Women’s Hospital in Boston, and colleagues. Trials that selected for patients with elevated serum creatinine or impaired estimated glomerular filtration rate eGFR had mortality rates of 5.9 to 8.2 per 100 patient-years, whereas the rest of the trials had rates no higher than 3.3, the researchers reported online in the Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease.

via Medical News:Mortality Risk Quantified for Diabetes Plus Kidney Disease – in Cardiovascular, Diabetes from MedPage Today.

Declining GFR Linked to Mortality Risk After MI

Patients with chronic kidney disease had a significantly increased risk of death after myocardial infarction, and the risk increased as glomerular filtration rate (GFR) declined, a review of 103,000 myocardial infarction patients showed.

The excess mortality risk ranged from 17% to as much as 500% as the severity of chronic kidney disease (CKD) increased. CKD predicted heightened mortality regardless of the presence or absence of ST-segment elevation.

via Medical News: ASN: Declining GFR Linked to Mortality Risk After MI – in Meeting Coverage, ASN from MedPage Today.

Watch that GFR.