Survival strategies

Diet and Healthy Aging

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In the journal Nature Medicine this week there was an important open-access publication about a large combined cohort of over 105,000 health professionals prospectively followed for 30 years. Only 9.3% reached the age of 70 years with “healthy aging” —without 11 major chronic diseases and no impairment of cognitive or physical function or mental health. Our Diet and Healthy Aging Eric Topol, MD – https://erictopol.substack.com/p/our-diet-and-healthy-aging

Dr. Eric Topol’s assessment of this study is well balanced and thoughtfully written. His bio is here: https://www.scripps.edu/faculty/topol/

Healthy aging in this study is described as reaching age 70 without developing any of 11 major diseases: cancer (except for non-melanoma skin cancers), diabetes, heart attack, coronary artery disease, congestive heart failure, stroke, kidney failure, chronic obstructive pulmonary disease, Parkinson disease, multiple sclerosis and amyotrophic lateral sclerosis.

My Half-Birthday is coming up soon. I’ll be 70.5 years young. The biggest take home lesson for me is this:

Beer is better for you than pizza.

Ah, Houston, we’ve had a problem (Scary Charts 03.10.25)

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Source – https://www.apolloacademy.com/there-is-a-significant-need-for-retirement-savings-in-the-us/

Short of forcing people to save for retirement, Social Security remains the safety net for those who lack access to retirement vehicles or don’t have the means to save. – How Many Americans Don’t Save For Retirement? https://awealthofcommonsense.com/2025/03/how-many-americans-dont-save-for-retirement/

TBH, Social Security is a much higher portion of our retirement income than I had planned for.

Men Are Bad at Retirement

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When envisioning retirement, many men imagine traveling, playing with grandchildren and driving that sexy convertible they can finally afford. The reality? For those over 70, 94% of adults watch television every day, with nearly 10% spending more than nine hours a day staring at the shows.

Men die earlier, with an average life expectancy of 73.5 years, according to a 2021 study. That’s about five years earlier than women in the U.S. One study found that men who considered themselves “traditional” men — unemotional and self-reliant — were more likely to ignore medical problems, and suffered worse health outcomes than women. And the problem gets worse as they get older. About 74% of men 55 and older go to the doctor for an annual check-up, compared to 43% of men age 35-54 and 26% of men age 18-34. Why So Many Men are Bad at Retirement https://getpocket.com/explore/item/why-so-many-men-are-bad-at-retirement?

This is an interesting article. Just more reasons why I’m not retired.

Retire. Watch TV all day long. Repeat.

Yikes.

There Are Health Related Benefits to Working Past Age 65

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“Our perceptions of working after age 65 have changed over time, and these data suggest that most older adults who are still able to work after the traditional retirement age derive health-related benefits from doing so,” said poll director Jeffrey Kullgren, M.D., M.P.H., M.S., a primary care physician at the VA Ann Arbor Healthcare System and associate professor of internal medicine at U-M. “As we learn more about how loneliness, lack of social connection and isolation intertwine with physical and mental health in older adults, the role of work is important to consider.”Michigan Medicine – University of Michigan. “As more Americans work later in life, poll shows positive health impacts, especially for those over 65.” ScienceDaily. http://www.sciencedaily.com/releases/2025/02/250211141049.htm (accessed February 12, 2025)

National Poll on Healthy Aging Team. The Intersection of Work, Health, and Well-Being. University of Michigan National Poll on Healthy Aging. January/February 2025. Available at https://dx.doi.org/10.7302/25186

It’s 8:00 AM…yes, I’m Thinking About Drinking

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Alcohol use is ubiquitous in the United States, with 84% of adults reporting use at some point. Alcohol use disorder (AUD) is a serious and persistent disease at the extreme end of alcohol use that contributes heavily to the burden on the healthcare system, with more than 200,000 hospitalizations each year due to the condition. About 6% of people in the United States have AUD. However, only 7.6% of patients with AUD seek treatment, although several pharmacologic and nonpharmacologic treatment options are available. Stephen Soreff. Rapid Rx Quiz: Alcohol Use Disorder Treatments – Medscape – Dec 30, 2024. https://reference.medscape.com/viewarticle/1002119

  • Overall mortality rates increased from 10.7 (95% CI, 10.6-10.8) per 100,000 in 1999 to 21.6 (95% CI, 21.4-21.8) per 100,000 in 2020, representing a significant twofold increase.
  • Adults aged 55-64 years demonstrated both the steepest increase and highest absolute rates in both 1999 and 2020.
  • American Indian and Alaska Native individuals experienced the steepest increase and highest absolute rates among all racial groups.
  • The West region maintained the highest absolute rates in both 1999 and 2020, despite the Midwest showing the largest increase. Edited by Lora McGlade. US Alcohol-Related Deaths Double Over Two Decades, With Notable Age and Gender Disparities – Medscape – November 21, 2024. https://www.medscape.com/viewarticle/us-alcohol-related-deaths-double-over-two-decades-notable-2024a1000l98?

Nearly 500 years ago, Swiss physician and chemist Paracelsus expressed the basic principle of toxicology: “All things are poison and nothing is without poison; only the dose makes a thing not a poison.” This is often condensed to: “The dose makes the poison.” It means that a substance that contains toxic properties can cause harm only if it occurs in a high enough concentration. https://www.chemicalsafetyfacts.org/health-and-safety/the-dose-makes-the-poison/

Dry January? If you’re doing this trendy behavior you know you drank too much this past holiday season.

Cancer warnings on alcohol? No one will read them.

Trust your intuition. If you’ve ever felt like you drink too much alcohol then you do.

1-800-662-HELP or text 988 for SAMHSA’s National Helpline.

Smartphones, Ultra-Processed Foods, Diminished Family Bonds and Mental Wellness

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As mental well-being has remained largely static across the world since 2021, so too have the rankings of countries. At the top of the rankings are many Latin American and African countries while much of the core Anglosphere ranks in the bottom quartile. With national wealth indicators such as per capita GDP negatively correlated with average mental well-being scores (see our 2021 report), this year we have made substantial progress in our understanding of why this is so. Two key findings published in Rapid Reports in 2023 show that younger age of first smartphone ownership and ultra-processed food consumption are two major contributors to our mental health challenges. In wealthier countries, the age of first smartphone ownership is much younger and ultra-processed food consumption much higher. Other contributing factors are the relatively diminished family relationships in wealthier countries that are highlighted in our 2022 annual report. The Mental State of the World in 2023 – https://mentalstateoftheworld.report/2023_read/

Another Sunday morning, just reading and connecting the dots.

I’ve downloaded several of these reports and plan to do a deep dive later.

Read these reports and think about it.

Now do something about it.

How To Feel Young at 70 (you read articles like this one)

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Sofiya Milman is director of Human Longevity Studies at the Institute for Aging Research at Albert Einstein College of Medicine. She studies people known as “superagers” —95 and older. “As a group, they have a very positive outlook on life” and are notably resilient, like Jaffe, she told me.

Qualities associated with resilience in older adults include optimism and hopefulness, an ability to adapt to changing circumstances, meaningful relationships, community connections, and physical activity, according to a growing body of research on this topic. A Centenarian Thrives Living Alone, Active and Engaged – https://kffhealthnews.org/news/article/centenarian-thrives-living-alone-older-adults/

Hilda Jaffe 102 lives alone and is thriving.

I need to improve my level of physical activity if I want to become a superager.

Humans are Difficult

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That day at the Costco checkout, I paid for my groceries at a human-powered cash register and received the tiny oxytocin boost that comes from a random interaction with strangers, the kind that Mehret Biruk is always raving about, those small insignificant moments of connection that add to the richness of life…

This interaction made me realize that much of what I explore in this newsletter is about embracing inefficiencies—making phone calls instead of texting, planning your route ahead of time instead of relying on a GPS, waiting to check your email from a desktop instead of on-the-go, letting people know that you can’t always be instantly available across various communication platforms.

We live in a world obsessed with optimization. An era of contactless everything. This holiday season, lean into the inefficiencies. Make eye contact with strangers. Take your AirPods out of your ears and make small talk with the cashier instead of scanning your own groceries. Chat with the kind humans handing out samples at Costco. Choose human connection, however uncomfortable that may be. You might be pleasantly surprised. Humans are difficult – https://substack.com/@carmellaguiol

Choose human connection.

GLP-1 – Compounded or Brand-Name?

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Caroline Apovian, MD, co-director of the Center for Weight Management and Wellness at Brigham and Women’s Hospital and professor of medicine at Harvard Medical School, Boston.

“Doctors who are obesity medicine specialists like myself in academic centers do not prescribe compounded semaglutide or tirzepatide,” she said.

Many of the compounded prescriptions, she said, come from telehealth virtual–only companies interested in profits.

GLP-1 Prescribing Decisions: Compounded or Brand-Name? – Medscape – November 14, 2024 – https://www.medscape.com/viewarticle/glp-1-prescribing-decisions-compounded-or-brand-name-2024a1000krd?

To be clear, all of my GLP-1 posts are not anti-pharma. If you can afford these medications and they work for you on your weight loss journey that’s great. Just be aware of the possible side effects and the fact these medications are for life. You will regain all that you’ve lost if you stop taking the drug.

Here’s the link to Complications? What Complications? (just another GLP-1 receptor agonist post)