Thursday 08.12.21 – More Diabetes Research for Your Reading Pleasure

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Prevalence and incidence of microvascular and macrovascular complications over 15 years among patients with incident type 2 diabetes

Our findings show that a substantial proportion of patients had existing complications including CKD, stable angina, and peripheral neuropathy at the time of T2D diagnosis. Results also show that among those newly diagnosed with T2D, the highest incidence rates of complications included peripheral neuropathy, CKD, and CVD (myocardial infarction, unstable angina, and stroke).

Time to incidence of microvascular and macrovascular complications was only a few years; peripheral vascular disease, stable angina, CKD, and peripheral neuropathy developed earlier in the disease course.

BMJ Open Diabetes Research and Care – http://dx.doi.org/10.1136/bmjdrc-2020-001847

Diabetic Ketoacidosis and Mortality in People With Type 1 Diabetes and Eating Disorders

CONCLUSIONS Adolescents and young adults with type 1 diabetes and eating disorders have more than triple the risk of DKA and nearly sixfold increased risk of death compared with their peers without eating disorders.

Diabetes Care 2021 Aug; 44(8): 1783-1787. https://doi.org/10.2337/dc21-0517

Fenofibrate Use Is Associated With Lower Mortality and Fewer Cardiovascular Events in Patients With Diabetes: Results of 10,114 Patients From the Korean National Health Insurance Service Cohort

Diabetes Care 2021 Aug; 44(8): 1868-1876. https://doi.org/10.2337/dc20-1533

I’ve been out of town the past three weekends in a row. Prior to taking these trips I was feeling a bit burned out. I had little desire to continue my research activities. I had even less desire to write or post to my blogs. But as suddenly as my energy levels dipped, the mojo came back.

Hiatus is over. The SupremeCmdr is back.

Trends in Consumption of Ultraprocessed Foods (not good news)

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The calories that children and adolescents consumed from ultraprocessed foods jumped from 61% to 67% of total caloric intake from 1999 to 2018, according to a new study from researchers at the Friedman School of Nutrition Science & Policy at Tufts University. Published August 10, 2021, in JAMA, the study analyzed dietary intake from 33,795 children and adolescents nationwide.

Tufts University. “Ultraprocessed foods now comprise 2/3 of calories in children and teen diets.” ScienceDaily. http://www.sciencedaily.com/releases/2021/08/210810110955.htm (accessed August 10, 2021).

The largest spike in calories came from such ready-to-eat or ready-to-heat dishes as takeout and frozen pizza and burgers: from 2.2% to 11.2% of calories. The second largest spike in calories came from packaged sweet snacks and desserts, the consumption of which grew from 10.6% to 12.9%.

Frozen pizza and burgers? Is this a problem?

Findings  In this serial cross-sectional study of nationally representative data from 33 795 US youths aged 2-19 years, the estimated percentage of total energy consumed from ultraprocessed foods increased from 61.4% to 67.0%, whereas the percentage of total energy consumed from unprocessed or minimally processed foods decreased from 28.8% to 23.5%.

https://jamanetwork.com/journals/jama/article-abstract/2782866

We are doomed.

Just Another Sweet Sunday

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RESEARCH DESIGN AND METHODS We linked data from two Danish type 2 diabetes cohorts, the Anglo-Danish-Dutch Study of Intensive Treatment in People With Screen-Detected Diabetes in Primary Care (ADDITION-Denmark) and the Danish Centre for Strategic Research in Type 2 Diabetes (DD2), to national health care registers. The Michigan Neuropathy Screening Instrument questionnaire (MNSIq) was completed at diabetes diagnosis in ADDITION-Denmark and at a median of 4.6 years after diagnosis of diabetes in DD2. An MNSIq score ≥4 was considered as indicative of DPN. Using Poisson regressions, we computed incidence rate ratios (IRRs) of CVD and all-cause mortality comparing MNSIq scores ≥4 with scores <4. Analyses were adjusted for a range of established CVD risk factors.

RESULTS In total, 1,445 (ADDITION-Denmark) and 5,028 (DD2) individuals were included in the study. Compared with MNSIq scores <4, MNSIq scores ≥4 were associated with higher incidence rate of CVD, with IRRs of 1.79 (95% CI 1.38–2.31) in ADDITION-Denmark, 1.57 (CI 1.27–1.94) in the DD2, and a combined IRR of 1.65 (CI 1.41–1.95) in a fixed-effect meta-analysis. MNSIq scores ≥4 did not associate with mortality; combined mortality rate ratio was 1.11 (CI 0.83–1.48).

CONCLUSIONS The MNSIq may be a tool to identify a subgroup within individuals with newly diagnosed type 2 diabetes with a high incidence rate of subsequent CVD. MNSIq scores ≥4, indicating DPN, were associated with a markedly higher incidence rate of CVD, beyond that conferred by established CVD risk factors.

Diabetic Polyneuropathy Early in Type 2 Diabetes Is Associated With Higher Incidence Rate of Cardiovascular Disease: Results From Two Danish Cohort Studies — Diabetes Care 2021 Jul; 44(7): 1714-1721. https://doi.org/10.2337/dc21-0010

The results for the 500 young adult participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth 2 (TODAY 2) study were published online July 28 in the New England Journal of Medicine by the TODAY study group.At follow-up — after originally participating in the TODAY trial when they were young teenagers — they had a mean age of 26.4 years.

At this time, more than two thirds had hypertension and half had dyslipidemia.

Overall, 60% had at least one diabetic microvascular complication (retinal disease, neuropathy, or diabetic kidney disease), and more than a quarter had two or more such complications.

‘Shocking’ Early Complications From Teen-Onset Type 2 Diabetes – Medscape – Jul 28, 2021. – https://www.medscape.com/viewarticle/955590?src=rss#vp_1

Scam?

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Hello,Hope you’re staying safe Are you aware of the ongoing Covid-19 Benefit Relief Program, the 2021 $1.050 Billion winner of the Mega Millions Jackpot (POWER BALL). We are donating $50,200 each to 300 random individuals. We congratulate you because your Cell# was randomly picked after a spin ball. We have decided to help due to COVID-19 pandemic. We are sending $50,200 to you as one of the selected 300 individuals. To verify/claim your winning, kindly text your full name to the Agent in charge, MR ROBERT (512) 580-6091 . So basically we have won something like this some times last 2 year and we decided to give back to the community but many scammers had to take advantage of the money so this time around to claim your funds we have partner with I’d.me to verify the identity of any one we would be giving the money..so text MR ROBERT now with your I’d card info and image to get you verified and get access to your funds.

My Only Other Comment on Severe Breakthrough Covid-19 Infections Post-vaccination (is actually a comment from Dr. Monica Gandhi)

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Why isn’t our mainstream media reporting this data?

Why is our mainstream media obsessed with their focus on fear of variants and shame to encourage more vaccinations?

Why?

A Moral Cesspool

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From zero in 1993 to $1.728 trillion in 2021: this is the predatory financialization of higher education which has enriched lenders, Wall Street and the Higher Education Cartel

America Is a Moral Cesspool, and Student Loans Prove It — https://charleshughsmith.blogspot.com/2021/07/america-is-moral-cesspool-and-student.html

Way back in the Dark Ages I borrowed a total of $8000.00 and worked summers and during the school years to pay for my college education. It took me ten years of payments at $69.72 a month to pay the loan off. I promised myself no matter the hardship my own children would not borrow money for their undergraduate degrees (medical school different story). There were reasons why I drove a 2006 Ford Taurus for 15 effing years.

One of the joys of aging is you get to a point where you say what you want to say and the hell with everyone else. Charles Hugh Smith is one of us who possess critical thinking skills and will always tell it like it is. Check out his blog.

And this is a perfect time to remind all of my readers that the opinions expressed in this and my other blog are mine alone and do not represent the views of any corporate entity that I may or may not be involved with either in the present or past.

I should play more and work less. https://garyskitchen.net/2021/07/24/stress-reduction/ I’m starting to become more cynical than usual.

The Great Resignation

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In April, about 649,000 retail workers left their jobs—a record number of resignations for the industry. It was yet another inflection point in a broader trend sweeping workplaces, as employees reevaluate their relationship to work and act on the burnout induced by the pandemic.

Why I decided to quit my retail job and join the Great Resignation — https://www.fastcompany.com/90658770/why-i-decided-to-quit-my-retail-job-and-join-the-great-resignation

Interesting perspective from an “essential” worker. And the trend is not limited to retail.

Hospitality jobs are unpopular, and raising the wage may not be enough to lure many former workers back. 38% of former hospitality workers report that they are not even considering a hospitality job for their next position. These workers are transitioning out of the industry in search of a different work setting (52%), higher pay (45%), better benefits (29%), and more schedule flexibility (19%). Over 50% of former hospitality workers who are looking for other work say that no pay increase or incentive would make them return to their old restaurant, bar, or hotel job.

Q2 2021 United States Job Market Report — https://www.joblist.com/jobs-reports/q2-2021-united-states-job-market-report
Not just no but hell no.

No wonder my up line supervisor got nervous when I told her I was thinking more about retirement.

Travel Advisory for Oklahoma – Updated 07.20.21(this is personal and not the US State Department)

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The Delta VOC has arrived big time and I might be returning to crowd avoidance and curbside everything soon.

Northeast Oklahoma is likely the “tip of the spear” as the delta variant has taken hold in the state, Dr. Justin Mitchell of Integris Miami Hospital said last week. There, COVID-19 beds are full again — there are even more patients now than there were in January and February, when the pandemic was at its height in Oklahoma.

Oklahoma is facing another COVID-19 surge — https://www.oklahoman.com/story/news/2021/07/19/oklahoma-faces-another-covid-surge-leaving-unvaccinated-risk/8017015002/?utm_source=oklahoman-Daily%20Briefing&utm_medium=email&utm_campaign=daily_briefing&utm_term=hero&utm_content=OKLAHOMA-OKLAHOMACITY-NLETTER65

ATTENTION PLEASE (it ain’t over)

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In a sick twist of capitalism, this sharp decrease in patient volumes through the emergency department and occupying hospital beds, while non-emergency operations were put on hold, lead to decreased revenue for hospitals and physician groups.

With a lack of revenue and a lack of foresight for the possibility of further surges and the arcane and length process of applying for hospital credentials, that lead to hospitals cutting staff including nurses and physician groups cutting hours and pay or even firing physicians.

COVID Isn’t Over, And Why That Will Impact Everyone — https://tnicholsmd.medium.com/covid-isnt-over-and-why-that-will-impact-everyone-ce94766669df

We have staffing shortages in our hospitals that include not just physicians but nurses, respiratory specialists, etc. Dr. Nichols calls this “a sick twist of capitalism”. I disagree. It’s just capitalism. Capitalism worked well for several hundred years, but times change, and systems eventually become corrupt. Corrupt systems then attract corrupt individuals or gradually corrupt unsuspecting souls to perpetuate the system. Welcome to to the world of Predatory Capitalism. Eat or be eaten. Capitalism lacks compassion.

Whew. Now that I’ve gotten that off my chest back to our original programming.

Be virus aware even if you are vaccinated. You might consider masking up again while indoors, amongst crowds, etc. The situation is worse in different parts of the world. Be aware of the situation where you live and where you travel. I was in a local shopping mall for the first time since some time prior to March 2020. A small minority of us were wearing masks. The vast majority of shoppers were behaving as if the pandemic was over. It ain’t over.

I did notice that masks were on sale. You might want to pick up a few before the price goes back up.

But so many people remain unvaccinated that, nationwide, cases have more than doubled in recent weeks — a jump driven not just by Delta, but also the country’s lapsing of mitigation efforts and people traveling and reconnecting socially. Even states like Massachusetts that have comparatively high vaccination rates have started seeing upticks in cases.

How Delta is pushing the U.S. into a new phase of the Covid-19 pandemic — https://www.statnews.com/2021/07/19/delta-vaccines-new-phase-pandemic/?utm_campaign=rss