Stress related disorders and risk of cardiovascular disease: population based, sibling controlled cohort study

BMJ 2019; 365 doi: (Published 10 April 2019) Cite this as: BMJ 2019;365:l1255

Conclusion Stress related disorders are robustly associated with multiple types of cardiovascular disease, independently of familial background, history of somatic/psychiatric diseases, and psychiatric comorbidity.

This study is Open Access and a PDF can be downloaded at the link above.

Stress Changes Your Brain Structure!

In mice.

In the latest study, the researchers paired sets of mice together and then removed one mouse from each pair and subjected them to a mild amount of stress. They then returned the stressed mouse to the pair and observed the brains of both mice. The results showed that the stressed mouse experienced changes in a group of neurons located in the hippocampus, a brain area that plays a central role in memory and emotional response. The brain of the other mouse that hadn’t been stressed, but was now in the presence of its stressed partner, rapidly showed the same neuronal changes in its hippocampus. In effect, the brains of the unstressed mice mirrored the brains of the stressed mice.

Read the source article here.

Significant financial stress is associated with a 13-fold higher odds of having a heart attack

Both work stress and financial stress were associated with a higher risk of acute myocardial infarction. The odds of myocardial infarction was 5.6 times higher in patients with moderate or severe work stress compared to those with minimal or no stress. Patients with significant financial stress had a 13-fold higher odds of having a myocardial infarction.

Small study with interesting findings.

Life Stressors Increase Mortality Risk

When they looked at life stressors and mortality, they found that 510 persons said they experienced none of the 10 major life events, and over the course of the follow-up, 159 of them died. Of the 853 people who listed one major life event, 276 died — a crude nonsignificant 4% increased risk of all-cause mortality compared with those having no life stressors.

Of the 588 individuals who experienced two life stressors, 213 died, translating to a crude 21% increased risk that also failed to achieve statistical significance. The researchers identified 257 people who experienced three life stressors, and 101 of them died, a crude 50% increase in all-cause mortality that was significant. They also reported that 177 persons experienced four or more life events, and 78 of that group died, translating to a crude all-cause mortality increase was 60% higher than those with no life stressors, also significant.

When the researchers adjusted for age and sex, the significant findings held for those with three or more events. When the figures were also adjusted for glycemic parameters, type 2 diabetes prevalence, body mass index, hypertension and cardiovascular disease prevalence, significance remained for those with four or more life stressor events — a 38% increased risk (95% CI 1.0-1.8), Rutters said.

via Life Stressors Increase Mortality Risk.

Stress Increases IHD Risk in Women

Medical News: Work Stress Adds to Women’s Heart Disease Risk – in Cardiovascular, Prevention from MedPage Today

On-the-job pressure significantly increases the likelihood that women will develop ischemic heart disease, a large Danish study found.

Compared with women who felt their workplace pressure was suitable, those who reported that the pressure was much too high had a nearly 50% increased risk of developing ischemic heart disease (HR 1.47, 95% CI 1.14 to 1.88), according to Karen Allesøe, PhD, and colleagues from Glostrup University Hospital.