Vitamin D and Mortality Risk in People With CVD

Summary:     A normal intake of vitamin D can reduce the risk of early death substantially in people with cardiovascular disease, a new study shows. The study concludes that people who have suffered from cardiovascular disease, and have a normal intake of vitamin D, reduce their risk of morality as a consequence of the disease by 30 per cent.

Source article can be found here.


Vitamin D Dosing: Too Low to Matter?

Autier and colleagues found that vitamin D deficiency, in the observational studies, was associated with cardiovascular diseases, inflammation, glucose metabolism disorders, infectious diseases, mood disorders, declines in cognitive function, and even all-cause mortality.

With the exception of colorectal cancer, being vitamin D sufficient did not appear to reduce the risk of developing various types of cancer.

Vitamin D sufficiency was associated with a lower risk of cardiovascular events (up to 58%), diabetes (up to 38%), colorectal cancer (up to 33%), and all-cause mortality (29%).

via Vitamin D Dosing: Too Low to Matter?.

Race Has Role in Vitamin D Link to Heart Risk

A 10-ng/mL decrease in 25(OH)D levels was associated with an increased risk of coronary heart disease events in whites (HR 1.26, 95% CI 1.06-1.49) and those with Chinese ancestry (HR 1.67, 95% CI 1.07-2.61), according to Ian de Boer, MD, of the University of Washington in Seattle, and colleagues.

But a similar relationship was not seen among blacks (HR 0.93, 95% CI 0.73-1.20) and Hispanics (HR 1.01, 95% CI 0.77-1.33), the investigators reported in the July 10 issue of the Journal of the American Medical Association.

via Race Has Role in Vitamin D Link to Heart Risk.

A couple of years ago I asked my primary care physician to check my Vitamin D level.  We were both surprised to discover the fact I was Vitamin D deficient.  Since then I’ve been on daily Vitamin D supplementation of 5000iu.

Simple blood test.  Just do it.

The researchers advised caution in interpreting the results in the Chinese and Hispanic participants because of the low sample sizes.

I’m still going to take my supplement.

Low Vitamin D Causes High BP

Note that this large genetic analysis demonstrated that individuals with genes linked to lower vitamin D levels are more likely to have hypertension mediated by low vitamin D, strengthening the argument for a causal link.

Be aware that the absolute effect of vitamin D levels on blood pressure was negligible, even though statistically significant.

via Low Vitamin D Causes High BP, Study Shows.

Strong Associations of Vitamin D Concentrations with Mortality

Conclusions: In this large cohort study, serum 25(OH)D concentrations were inversely associated with all-cause and cause-specific mortality. In particular, vitamin D deficiency [25(OH)D concentration

via Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study.

Vitamin D Level Predicts Death in CABG

Patients with vitamin D deficiency or insufficiency, defined by levels of 25(OH)D, had significantly higher 90-day mortality after CABG than those who had sufficient levels of the vitamin (OR 5.24 and OR 4.61, respectively), Takuhiro Moromizato, MD, of Brigham and Women’s Hospital in Boston, and colleagues reported during an oral session at the Society of Critical Care Medicine meeting.

The study was limited by its observational design, which can’t prove causality, and by the potential for selection bias and unmeasured confounders.

via Vitamin D Level Predicts Death in CABG.