Autier and colleagues found that vitamin D deficiency, in the observational studies, was associated with cardiovascular diseases, inflammation, glucose metabolism disorders, infectious diseases, mood disorders, declines in cognitive function, and even all-cause mortality.
With the exception of colorectal cancer, being vitamin D sufficient did not appear to reduce the risk of developing various types of cancer.
Vitamin D sufficiency was associated with a lower risk of cardiovascular events (up to 58%), diabetes (up to 38%), colorectal cancer (up to 33%), and all-cause mortality (29%).
A 10-ng/mL decrease in 25(OH)D levels was associated with an increased risk of coronary heart disease events in whites (HR 1.26, 95% CI 1.06-1.49) and those with Chinese ancestry (HR 1.67, 95% CI 1.07-2.61), according to Ian de Boer, MD, of the University of Washington in Seattle, and colleagues.
But a similar relationship was not seen among blacks (HR 0.93, 95% CI 0.73-1.20) and Hispanics (HR 1.01, 95% CI 0.77-1.33), the investigators reported in the July 10 issue of the Journal of the American Medical Association.
A couple of years ago I asked my primary care physician to check my Vitamin D level. We were both surprised to discover the fact I was Vitamin D deficient. Since then I’ve been on daily Vitamin D supplementation of 5000iu.
Simple blood test. Just do it.
The researchers advised caution in interpreting the results in the Chinese and Hispanic participants because of the low sample sizes.
I’m still going to take my supplement.
Note that this large genetic analysis demonstrated that individuals with genes linked to lower vitamin D levels are more likely to have hypertension mediated by low vitamin D, strengthening the argument for a causal link.
Be aware that the absolute effect of vitamin D levels on blood pressure was negligible, even though statistically significant.
Conclusions: In this large cohort study, serum 25(OH)D concentrations were inversely associated with all-cause and cause-specific mortality. In particular, vitamin D deficiency [25(OH)D concentration
Conclusion: The current prospective study suggests that vitamin D metabolism may play a role in T2D pathogenesis independently of known risk factors. This trial was registered at clinicaltrials.gov as NCT01508481.
Patients with vitamin D deficiency or insufficiency, defined by levels of 25(OH)D, had significantly higher 90-day mortality after CABG than those who had sufficient levels of the vitamin (OR 5.24 and OR 4.61, respectively), Takuhiro Moromizato, MD, of Brigham and Women’s Hospital in Boston, and colleagues reported during an oral session at the Society of Critical Care Medicine meeting.
The study was limited by its observational design, which can’t prove causality, and by the potential for selection bias and unmeasured confounders.
Patients receiving both calcium and vitamin D had a 9% lower mortality rate through 3 years of treatment than those not receiving vitamin D (HR 0.91, 95% CI 0.84 to 0.98), according to Lars Rejnmark, MD, PhD, of Aarhus University in Aarhus, Denmark, and colleagues.
How about a non-prescription supplement and vitamin questionnaire?