Vitamin D Hypothesis – A Role in COVID-19 Mortality Rates?

Vitamin D Levels Appear to Play Role in COVID-19 Mortality Rates

By analyzing publicly available patient data from around the globe, Backman and his team discovered a strong correlation between vitamin D levels and cytokine storm — a hyperinflammatory condition caused by an overactive immune system — as well as a correlation between vitamin D deficiency and mortality.

The research is available on medRxiv, a preprint server for health sciences.

The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality

In conclusion, we found significant crude relationships between vitamin D levels and the number COVID-19 cases and especially the mortality caused by this infection. The most vulnerable group of population for COVID-19, the aging population, is also the one that has the most deficit Vitamin D levels.

Vitamin D has already been shown to protect against acute respiratory infections and it was shown to be safe. It should be advisable to perform dedicated studies about vitamin D levels in COVID-19 patients with different degrees of disease severity.

Many years ago I approached my former personal care physician and asked to have my Vitamin D level checked.

“What the hell for?”

“I would like to know my Vitamin D blood level to see if I need to take a supplement.”

“Just get outside in the sun for around 20 minutes a day.”

“Just order the test.”

And he did.  Less than a week later Doc called me back to let me know I had Vitamin D deficiency.  I’ve been taking a daily supplement since.

Vitamin D deficiency is now recognized as a pandemic. The major cause of vitamin D deficiency is the lack of appreciation that sun exposure in moderation is the major source of vitamin D for most humans. Very few foods naturally contain vitamin D, and foods that are fortified with vitamin D are often inadequate to satisfy either a child’s or an adult’s vitamin D requirement. Vitamin D deficiency causes rickets in children and will precipitate and exacerbate osteopenia, osteoporosis, and fractures in adults. Vitamin D deficiency has been associated with increased risk of common cancers, autoimmune diseases, hypertension, and infectious diseases. A circulating level of 25-hydroxyvitamin D of >75 nmol/L, or 30 ng/mL, is required to maximize vitamin D’s beneficial effects for health. In the absence of adequate sun exposure, at least 800–1000 IU vitamin D3/d may be needed to achieve this in children and adults. Vitamin D2 may be equally effective for maintaining circulating concentrations of 25-hydroxyvitamin D when given in physiologic concentrations.

The American Journal of Clinical Nutrition, Volume 87, Issue 4, April 2008, Pages 1080S–1086S, https://doi.org/10.1093/ajcn/87.4.1080S
Published: 01 April 2008

An interesting hypothesis that needs more research.

Update 05.16.20

Journal Reference:

  1. E. Laird, J. Rhodes, R.A. Kenny. Vitamin D and Inflammation: Potential Implications for Severity of Covid-19. Irish Medical Journal, 2020; 113 (5): P81 [link]

Journal Reference:

  1. Petre Cristian Ilie, Simina Stefanescu, Lee Smith. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clinical and Experimental Research, 2020; DOI: 10.1007/s40520-020-01570-8

 

 

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