Brugada Syndrome

A 36-year-old female presents to the ED after experiencing an episode of sudden syncope. The patient has no significant past medical history, and reports that she was walking to the end of her driveway to retrieve her mail when she suddenly collapsed to the ground. She recalls waking up on her driveway with concerned neighbors gathered around her…

http://www.emdocs.net/em3am-brugada-syndrome/

Dear Readers – another Saturday morning and this Grandpa Underwriter is back to his old tricks of reading about things that are WAY ABOVE his pay grade. There are two clinical scenarios in the article. Enjoy!

Nature Wants Us to be Fat

Evidence that Obesity and Diabetes are Driven by a Diet-Induced Biological Switch: How it Works and How it Might be Prevented — https://www.vumedi.com/video/evidence-that-obesity-and-diabetes-are-driven-by-a-diet-induced-biological-switch-how-it-works-and-h/

Blog post title is the same as the title of Dr. Richard J. Johnson’s book. The link takes you to a video that is approximately 37 minutes long. Enjoy!

New Wonder Drug! Treat Diabetes, Obesity AND Addiction – (yup another GLP-1 receptor agonist post)

Previous research has found that activating GLP-1 receptors in rats’ brain causes the animals to eat less of a high-sugar chow, which they would normally prefer over a less delicious but healthier bland meal when given the option. This suggests that GLP-1 makes unhealthy food less rewarding. Schmidt’s team found the same to be true with cocaine: rats that received a GLP-1 agonist took less cocaine when it was offered. The researchers are now repeating the experiments in rats addicted to opioids or fentanyl. Several other studies have shown that GLP-1 agonists cause rats to drink less alcohol and produce less dopamine when they do drink, suggesting that the activity is no longer as pleasurable.

…it’s too early to say whether people recovering from addiction would need to take an GLP-1 agonist for the rest of their lives, like people with diabetes do, or whether these drugs could be short-term treatments that curb cravings long enough for people to make lifestyle changes to stay sober. People who stop taking semaglutide for weight loss quickly gain the weight back, and study animals that stop taking it return to alcohol and drug use, but “I don’t think we know enough yet” in humans, Simmons says.

Could New Weight-Loss Drugs like Ozempic Treat Addiction? — https://www.scientificamerican.com/article/could-new-weight-loss-drugs-like-ozempic-treat-addiction1/

The rest of this post is a repost of April Fools 2023 (this is a GLP-1 receptor agonist post). Enjoy!

Ozempic and a similar drug, Wegovy, are weekly shots you give yourself that cause the body to produce insulin. Insulin lowers blood sugar, slows digestion and makes people feel full. Carter-Williams tried it and was amazed.

“You are not hungry,” she says. “Like, I actually have to set timers to make sure that I do eat, because otherwise you actually forget to eat.”

‘You forget to eat’: How Ozempic went from diabetes medicine to blockbuster diet drug https://www.npr.org/2023/04/01/1166781510/ozempic-weight-loss-drug-big-business

Everyone wants the easy way out. I sometimes forget to eat but not because of a miracle drug. You wonder if those of us wanting to lose weight know you can’t stop taking this drug once you start it.

Patients discontinuing the use of weight-loss drugs such as Wegovy risk regaining their original body weight in about five years, a Novo Nordisk official said on Wednesday.

Novo Nordisk Says Stopping Obesity Drug May Cause Full Weight Regain in 5 Years–https://www.medscape.com/viewarticle/990267?src=rss

Side effects?

Just a few https://www.wegovy.com/taking-wegovy/side-effects.html

  • Possible thyroid tumors, including cancer.
  • Inflammation of your pancreas (pancreatitis)
  • Gallbladder problems
  • Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin
  • Kidney problems (kidney failure)
  • Serious allergic reactions
  • Change in vision in people with type 2 diabetes.
  • Increased heart rate
  • Depression or thoughts of suicide.

So if you want to lose weight by taking a GLP-1 receptor agonist remember the risks of side effects including the real possibility of having to take a drug that costs up to $1600.00 a month for the rest of your life.

Good luck with that.

As an FYI this drug class is being investigated by the EU for a small number of cases reporting suicidal ideation https://www.latimes.com/business/story/2023-07-10/ozempic-weight-loss-drugs-probed-over-reports-of-suicidal-thoughts.

But we already knew this.

Why People Stop Using Drugs Like Ozempic – Wired (yet another GLP-1 receptor agonist post)

One study looked at GLP-1 RAs prescribed in the UK between 2009 and 2017. Out of the 589 patients who started taking a GLP-RA, 45 percent stopped taking the drug within 12 months, and 65 percent within 24 months. The same group of scientists also looked at people taking GLP-1 RAs in the US across a similar period of time. That study included a much larger group of diabetes patients but found that people quit taking the drugs at a similar rate as in the UK. Within 12 months, 47 percent of patients stopped taking their GLP-1 AR; after 24 months that figure was 70 percent. On average, people in that study spent around 13 months using the drug before they stopped taking it.

Why People Stop Using Drugs Like Ozempic —https://www.wired.com/story/ozempic-wegovy-quitting-weight-loss/?utm_source=pocket-newtab

For my last GLP-1 RA post see Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes — https://doi.org/10.2337/dc22-1710

To reduce the number of clicks the rest of this post is a repost of April Fools 2023 (this is a GLP-1 receptor agonist post). Enjoy!

Ozempic and a similar drug, Wegovy, are weekly shots you give yourself that cause the body to produce insulin. Insulin lowers blood sugar, slows digestion and makes people feel full. Carter-Williams tried it and was amazed.

“You are not hungry,” she says. “Like, I actually have to set timers to make sure that I do eat, because otherwise you actually forget to eat.”

‘You forget to eat’: How Ozempic went from diabetes medicine to blockbuster diet drug https://www.npr.org/2023/04/01/1166781510/ozempic-weight-loss-drug-big-business

Everyone wants the easy way out. I sometimes forget to eat but not because of a miracle drug. You wonder if those of us wanting to lose weight know you can’t stop taking this drug once you start it.

Patients discontinuing the use of weight-loss drugs such as Wegovy risk regaining their original body weight in about five years, a Novo Nordisk official said on Wednesday.

Novo Nordisk Says Stopping Obesity Drug May Cause Full Weight Regain in 5 Years–https://www.medscape.com/viewarticle/990267?src=rss

Side effects?

Just a few https://www.wegovy.com/taking-wegovy/side-effects.html

  • Possible thyroid tumors, including cancer.
  • Inflammation of your pancreas (pancreatitis)
  • Gallbladder problems
  • Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin
  • Kidney problems (kidney failure)
  • Serious allergic reactions
  • Change in vision in people with type 2 diabetes.
  • Increased heart rate
  • Depression or thoughts of suicide.

So if you want to lose weight by taking a GLP-1 receptor agonist remember the risks of side effects including the real possibility of having to take a drug that costs up to $1600.00 a month for the rest of your life.

Good luck with that. This joke’s on you.

As an FYI this drug class is being investigated by the EU for a small number of cases reporting suicidal ideation https://www.latimes.com/business/story/2023-07-10/ozempic-weight-loss-drugs-probed-over-reports-of-suicidal-thoughts.

But we already knew this.

More Random Thoughts on Retirement – June 2023

Another quiet Sunday and I’m thinking about retirement (again). Writers read a lot. I’ll typically have quite a number of books started in various stages of completion. Recently I started reading the first in a series of books titled The Write Quotes: The Writing Life. The quotes paint similarities of thoughts and experiences and are amazing. You realize you are never alone in any of life’s adventures.

Since 2021, more than 1.5 million seniors have reentered the workforce. There were about 10.6 million people ages 65 to 74 employed in 2020, according to 2021 data from the U.S. Labor Department.

That number is expected to increase.

Retiring from retirement: Whether for financial reasons or boredom, a growing number of older adults are rejoining the workforce — https://triblive.com/local/valley-news-dispatch/back-to-work-whether-for-financial-reasons-or-boredom-a-growing-number-of-older-adults-are-rejoining-the-workforce/

Just last month I came to the realization that (I am) Flunking Retirement. When 65 rolled around I started collecting a small corporate defined benefit pension. Years ago the monthly amount had a lot more purchasing power than it does now. Still, I feel fortunate to have this income stream.

In yesteryear, the pension was a staple of the American working class experience—reach retirement age and you could expect to live out your years modestly, yet comfortably, off of monthly payments from your former employer. However, since the 1980s, companies offering pensions are a dwindling breed. Instead, most employers offer defined contribution programs such as 401(k) plans. Only a handful of industries (such as the military, public works and education) still offer pension plans to their retirees.

Why Pensions Are Dying And How You Can Create Your Own —https://www.forbes.com/sites/forbesfinancecouncil/2023/06/05/why-pensions-are-dying-and-how-you-can-create-your-own/?sh=4970c87ec9d4

When I reached my US Social Security FRA (full retirement age) I didn’t retire nor start collecting benefits. Delaying social security payments until age 70 translates into about an 8% increase in benefits annually. If you’re healthy and you don’t need the income for necessities, it’s worth the wait.

Working longer is a powerful lever. Social Security benefits claimed at 70 instead of at 62 are at least 76 percent higher, and the additional years of work allow 401(k) assets to increase and reduce the period of time that the assets need to cover. In fact, my research shows that the vast majority of millennials will be fine if they work to age 70. And although that might sound old, it’s historically normal in another sense: Retiring at 70 leaves the ratio of retirement to working years the same as when Social Security was originally introduced.

Millennials and retirement: How bad is it? — https://www.politico.com/agenda/story/2018/06/07/millennials-preparing-for-retirement-000670/

Millennials are not the only generation ill-prepared for retirement.

America’s 65 million Generation Xers (born between 1965 and 1980) are confronted with a new set of financial challenges that are redefining their plans for retirement, just as they enter their final working years, according to Prudential Financial, Inc.’s latest Pulse research survey, “Gen X: Retirement Revised.”

Generation X confronts harsh new reality of retirement: unreadiness — https://news.prudential.com/generation-x-confronts-harsh-new-reality-retirement-unreadiness.htm

Remember A Plan is Not a Strategy – Update 08.03.22? Having a plan for retirement is great but not all plans turn out as planned. My last executive position ended up being my last executive position and trust me, that was not what I planned. It’s a good thing that my strategy worked a lot better than my plans.

Stay tuned for the next installment of my random thoughts on retirement where I will document (finally) the integrative choices I’ve made that comprise my retirement strategy.

Quotes for Today – 05.19.23

“A master in the art of living draws no sharp distinction between his work and his play; his labor and his leisure; his mind and his body; his education and his recreation. He hardly knows which is which. He simply pursues his vision of excellence through whatever he is doing, and leaves others to determine whether he is working or playing. To himself, he always appears to be doing both.”

Lawrence Pearsall Jacks, educator and Unitarian minister.

“I love playing, it’s just part of me now, and it was then, at 13. I had the dream to play drums, and I ended up being that person, and I’m still that person.

Ringo Starr – 82 years young

Like I said, I think (I am) Flunking Retirement

(I am) Flunking Retirement

Participants with the most positive views of aging were living, on average, 7.5 years longer than those with the most negative views. 90%: the percentage of centenarians who were functionally independent in their 90’s.

People who live long lives can teach us how to live healthy lives.

Flunking Retirement – https://ysph.yale.edu/about-school-of-public-health/communications-public-relations/publications/public-health-magazine/article/flunking-retirement/

The source article is an interview with two Yale alumni who are still working at the age of 82. Both are youngsters when compared to…Willie who just turned 90 and still working.

Tirzepatide (another GLP-1 receptor agonist post)

Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes — https://doi.org/10.2337/dc22-1710

To reduce the number of clicks the rest of this post is a repost of April Fools 2023 (this is a GLP-1 receptor agonist post). Enjoy!

Ozempic and a similar drug, Wegovy, are weekly shots you give yourself that cause the body to produce insulin. Insulin lowers blood sugar, slows digestion and makes people feel full. Carter-Williams tried it and was amazed.

“You are not hungry,” she says. “Like, I actually have to set timers to make sure that I do eat, because otherwise you actually forget to eat.”

‘You forget to eat’: How Ozempic went from diabetes medicine to blockbuster diet drug https://www.npr.org/2023/04/01/1166781510/ozempic-weight-loss-drug-big-business

Everyone wants the easy way out. I sometimes forget to eat but not because of a miracle drug. You wonder if those of us wanting to lose weight know you can’t stop taking this drug once you start it.

Patients discontinuing the use of weight-loss drugs such as Wegovy risk regaining their original body weight in about five years, a Novo Nordisk official said on Wednesday.

Novo Nordisk Says Stopping Obesity Drug May Cause Full Weight Regain in 5 Years–https://www.medscape.com/viewarticle/990267?src=rss

Side effects?

Just a few https://www.wegovy.com/taking-wegovy/side-effects.html

  • Possible thyroid tumors, including cancer.
  • Inflammation of your pancreas (pancreatitis)
  • Gallbladder problems
  • Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin
  • Kidney problems (kidney failure)
  • Serious allergic reactions
  • Change in vision in people with type 2 diabetes.
  • Increased heart rate
  • Depression or thoughts of suicide.

So if you want to lose weight by taking a GLP-1 receptor agonist remember the risks of side effects including the real possibility of having to take a drug that costs up to $1600.00 a month for the rest of your life.

Good luck with that. This joke’s on you.