A total of 800 adults aged 18 to 55 or aged 65 and up were randomized to various combinations of low-dose or high-dose vaccines or placebo, given 56 days apart.
Adverse events were common, with fatigue, headache, myalgia, and injection-site pain reported most often. At day 29 after the first dose, the seroconversion rate was 99% or more in the younger cohort across dosing groups. Older vaccine recipients had a 96% seroconversion rate. At 57 days after the first dose, antibody titers had increased further.COVID-19: Single Dose of J&J Vaccine / Plasma / New Testing Requirement — https://www.jwatch.org/fw117413/2021/01/13/covid-19-single-dose-j-j-vaccine-plasma-new-testing
The J&J vaccine is in a multi-center, placebo-controlled, phase 1–2a trial. Here’s the link to the NEJM article https://www.nejm.org/doi/full/10.1056/NEJMoa2034201
From Stat Phase 3 results are coming soon.
There are two Phase 3 studies running. A 40,000-volunteer study of the one-dose vaccine, conducted in the U.S., is set to read out in the next two weeks. A second, equally big study is being conducted using the same vaccine given as two doses, each administered 57 days apart, in case the vaccine does not prove effective in a one-dose regimen or there are other advantages, such as the durability of the vaccine, to giving a second dose.https://www.statnews.com/2021/01/13/data-fuel-debate-over-whether-jjs-one-dose-covid-vaccine-will-measure-up/ — Data fuel debate over whether J&J’s one-dose Covid vaccine will measure up
And from the Medscape article.
Unlike the Pfizer/BioNTech and Moderna messenger RNA vaccines, the Johnson & Johnson product is a recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding a full-length and stabilized SARS-CoV-2 spike (S) protein.The Next Likely COVID-19 Vaccine Has Its Advantages — https://www.medscape.com/viewarticle/944151?src=rss
The coronavirus vaccine is finally a real thing and millions of people have already received it. While the rollout has the world cheering, researchers from Virginia Commonwealth University finds many Americans aren’t exactly chomping at the bit to be the first in line for the vaccine under an emergency use authorization. Their survey reveals 53.1 percent are definitely, likely, or somewhat unwilling to get the shot under emergency use conditions.Over half of U.S. adults ‘unlikely’ to get COVID vaccine under emergency use authorization — https://www.studyfinds.org/half-adults-unlikely-to-get-covid-vaccine/
Willingness to get the COVID-19 vaccine with and without emergency use authorization
Published:November 19, 2020 DOI:https://doi.org/10.1016/j.ajic.2020.11.018
We are so screwed.
Residents are the lowest-ranking doctors in a hospital. Stanford Medicine has about 1,300 across all disciplines. Only seven made the priority vaccination list, despite the fact that this week, residents were asked to volunteer for ICU coverage in anticipation of a surge in COVID-19 cases.
“Residents are patient-facing, we’re the ones who have been asked to intubate, yet some attendings who have been face-timing us from home are being vaccinated before us,” said Dr. Sarah Johnson, a third-year OB-GYN resident who has delivered babies from COVID-positive patients during the pandemic. “This is the final straw to say, ‘We don’t actually care about you.’”Only Seven of Stanford’s First 5,000 Vaccines Were Designated for Medical Residents – https://www.propublica.org/article/only-seven-of-stanfords-first-5-000-vaccines-were-designated-for-medical-residents
Stanford Medicine demonstrates how much they care about their residents.
Here’s an interesting breakdown of lessons learned.
In its earliest attempts at explaining the problem, Stanford’s administrators laid blame with the algorithm. Despite best intentions, they explained, the algorithm had made a mistake that the humans had to answer for.
This is a bit like blaming the hammer for missing the nail.3 lessons from Stanford’s Covid-19 vaccine algorithm debacle — https://www.statnews.com/2020/12/21/stanford-covid19-vaccine-algorithm/
Operation Warp Speed also experienced some hiccups.
“It looked very good on paper,” Perna said. “Paper plans are very good. Execution is where we learn, and we adapted accordingly.”‘I failed’: Operation Warp Speed leader takes responsibility for Covid-19 vaccine distribution confusion — https://www.statnews.com/2020/12/19/operation-warp-speed-leader-takes-sole-responsibility-for-covid-19-vaccine-distribution-confusion/?utm_campaign=rss
Remember “Everybody has a plan until they get punched in the mouth”
The most common side effects are injection site pain, fatigue, headache, muscle pain, and joint pain. Some people in the clinical trials have reported fever. Side effects are more common after the second dose; younger adults, who have more robust immune systems, reported more side effects than older adults.
To be clear: These side effects are a sign of an immune system kicking into gear. They do not signal that the vaccine is unsafe. To date there are no serious, long-term side effects associated with receipt of these vaccines, which will be closely monitored as their use expands.A side-by-side comparison of the Pfizer/BioNTech and Moderna vaccines — https://www.statnews.com/2020/12/19/a-side-by-side-comparison-of-the-pfizer-biontech-and-moderna-vaccines/?utm_campaign=rss
Post and link for informational purposes only. I will not waste my time trying to convince people that a virus doesn’t care about your gender, age, sexuality, religion, skin color, politics, net worth, personal freedoms, dietary preferences, or anything else.
A virus merely wants a host organism to infect.
Meanwhile at the CDC…
We don’t have enough vaccine yet for all health care workers. We will eventually, but we don’t yet.
Helen Keipp Talbot — who is known by her middle name — raised serious concerns during the meeting of the Advisory Committee on Immunization Practices about using the vaccines in the frail elderly, noting there are no data yet to suggest the vaccines work in this population.CDC advisory panel’s lone dissenter on why long-term care residents shouldn’t receive Covid-19 vaccine first — https://www.statnews.com/2020/12/03/cdc-advisory-panels-lone-dissenter-on-why-long-term-care-residents-shouldnt-receive-covid-19-vaccine-first/
Talbot is an associate professor of infectious diseases at Vanderbilt University. Despite the fact no one seems to be listening to her opinions, she makes some excellent observations.
Meanwhile back in Oklahoma