5 Classifications of Diabetes Proposed

  1. Severe autoimmune diabetes (formerly type 1 diabetes): affected 6% of patients in the derivation cohort; characteristics include early-onset disease, relatively low BMI, and GADA-positive
  2. Severe insulin-deficient diabetes: 18% of patients; GADA-negative but similar to cluster 1; lowest HOMA2-B scores
  3. Severe insulin-resistant diabetes: 15%; higher HOMA2-IR scores
  4. Mild obesity-related diabetes: 22%; obese, but not insulin resistant
  5. Mild age-related diabetes: 39%; older than other clusters, but largely similar to cluster 4

Quoted from  NEJM Journal Watch.

 

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